ArticleAngewandte Chemie (International ed. in English)2018
Switching Chemoselectivity: Using Mechanochemistry to Alter Reaction Kinetics.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
- Computational Model to Predict Reactivity under Ball-Milling Conditions.Journal of chemical theory and computation · 2025Article
- Tin can milling: low-tech mechanochemical synthesis of plant-based prepolymers incorporating perfluoropyridine.RSC advances · 2025Article
- Beyond Solution Chemistry: Mechanochemistry Enables Clustered Defects in Metal-Organic Frameworks.Inorganic chemistry · 2025Article
- Solventless Catalytic C-H and C-X Functionalization without Ball Milling.The Journal of organic chemistry · 2025Article
- Kinetics of the mechanochemical transformations in the "glycine - oxalic acid dihydrate" system revisited: The role of water.Frontiers in chemistry · 2025Article
- Mechanochemistry Drives Alkene Difunctionalization via Radical Ligand Transfer and Electron Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Liquid-assisted grinding enables a direct mechanochemical functionalization of polystyrene waste.Chemical science · 2024Article
- Synthesis and Structural and Optical Behavior of Dehydrohelicene-Containing Polycyclic Compounds.Molecules (Basel, Switzerland) · 2024Review
- Mechanochemistry Frees Thiourea Dioxide (TDO) from the 'Veils' of Solvent, Exposing All Its Reactivity.Molecules (Basel, Switzerland) · 2023Article
- Synthesis of precisely functionalizable curved nanographenes via graphitization-induced regioselective chlorination in a mechanochemical Scholl Reaction.Nature communications · 2023Article
- Article
- Manipulating Reaction Energy Coordinate Landscape of Mechanochemical Diaza-Cope Rearrangement.Molecules (Basel, Switzerland) · 2022Article
- Mechanochemical Organocatalysis: Do High Enantioselectivities Contradict What We Might Expect?ChemSusChem · 2022Review
- Ball-Milling-Enabled Reactivity of Manganese Metal*.Angewandte Chemie (International ed. in English) · 2021Article
- Mechanochemical transformation of planar polyarenes to curved fused-ring systems.Nature communications · 2021Article
- Mechanoredox Chemistry as an Emerging Strategy in Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Mechanochemical Thiocyanation of Aryl CompoundsACS omega · 2020Article
- Expedient Organocatalytic Aza-Morita-Baylis-Hillman Reaction through Ball-Milling.ACS sustainable chemistry & engineering · 2020Article
- Sustainable Synthesis of a Potent and Selective 5-HTThe Journal of organic chemistry · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A reaction manifold has been discovered in which the chemoselectivity can be altered by switching between neat milling and liquid assisted grinding (LAG) with polar additives. After investigation of the reaction mechanism, it has been established that this switching in reaction pathway is due to the neat mechanochemical conditions exhibiting different kinetics for a key step in the transformation. This proof of concept study demonstrates that mechanochemistry can be used to trap the kinetic product of a reaction. It is envisaged that, if this concept can be successfully applied to other transformations, novel synthetic processes could be discovered and known reaction pathways perturbed or diverted.
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