SynthesisPaediatric and perinatal epidemiology2018
Effects of prenatal marijuana exposure on neuropsychological outcomes in children aged 1-11 years: A systematic review.
Synthesis in Paediatric and perinatal epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Clinical Health Messaging for Perinatal Cannabis Use: Perspectives From Postpartum Individuals With Use During Early Pregnancy.Substance use & addiction journal · 2026Article
- Medical Cannabis During Pregnancy and Breastfeeding: Is the Concern Fully Evidence-Based?Biomedicines · 2026Article
- Prenatal Cannabis Exposure Shaping Altered Brain Connectivity: Neural Correlates of Cognitive and Mental Health Variability in Offspring.Research square · 2026Article
- Prenatal substance use during the COVID-19 pandemic in the United Kingdom: associations with depression, anxiety, and pandemic stressors.Frontiers in public health · 2026Article
- Cannabis Use During Early Pregnancy and Child Diagnoses of Depressive and Anxiety Disorders.Cannabis (Albuquerque, N.M.) · 2026Article
- Cannabis Retailer Advice on Blunt, Tobacco, and Cannabis Use During Pregnancy.JAMA network open · 2025Article
- Evidence on the effect of in-utero cannabis exposure in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- The Effect of Prenatal Marijuana Exposure on White Matter Microstructure and Cortical Morphology during Late Childhood.AJNR. American journal of neuroradiology · 2025Article
- Mental health clinicians' perceptions on patient motivations and intervention engagement for prenatal cannabis use: A mixed methods study.Drug and alcohol dependence reports · 2025Article
- Impact of healthy pregnancy and lifestyle in mothers on developmental delay in their offspring: a strength-based analysis of a longitudinal study among indigenous children in Australia.BMC pregnancy and childbirth · 2024Article
- Association of psychiatric and substance use disorders with cannabis use and cannabis use disorder during early pregnancy in northern California.Addiction (Abingdon, England) · 2024Observational
- Exploration of Differences between Women Who Do and Do Not Disclose Their Marijuana Use during Pregnancy.American journal of perinatology · 2024Article
- Intentions to Use Cannabis Postpartum: A Qualitative Study of Pregnant Individuals Who Used Cannabis During Early Pregnancy.Journal of women's health (2002) · 2024Article
- Exploring the associations between serious psychological distress and the quantity or frequency of tobacco, alcohol, and cannabis use among pregnant women in the United States.Preventive medicine · 2023Article
- Repeated Exposure to High-THCeNeuro · 2023Article
- Exploring preferences for different modes of cannabis use during early pregnancy: A qualitative study.Addictive behaviors · 2023Article
- Associations between Prenatal and Postnatal Exposure to Cannabis with Cognition and Behavior at Age 5 Years: The Healthy Start Study.International journal of environmental research and public health · 2023Article
- The ethics and management of cannabis use in pregnancy following decriminalisation and licensing for medical use: narrative review.BJPsych bulletin · 2023Review
- Association of cannabis use during pregnancy with severe acute respiratory syndrome coronavirus 2 infection: a retrospective cohort study.Addiction (Abingdon, England) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNormalisation of medicinal and recreational marijuana use has increased the importance of fully understanding effects of marijuana use on individual-and population-level health, including prenatal exposure effects on child development. We undertook a systematic review of the literature to examine the long-term effects of prenatal marijuana exposure on neuropsychological function in children aged 1-11 years.
methodsPrimary research publications were searched from Medline, Embase, PsychInfo, CINAHL EbscoHost, Cochrane Library, Global Health and ERIC (1980-2018). Eligible articles documented neuropsychological outcomes in children 1-11 years who had been prenatally exposed to marijuana. Studies of exposure to multiple prenatal drugs were included if results for marijuana exposure were reported separately from other substances. Data abstraction was independently performed by two reviewers using a standardised protocol.
resultsThe eligible articles (n = 21) on data from seven independent longitudinal studies had high quality based on the Newcastle-Ottawa Scale. Some analyses found associations (P < 0.05) between prenatal marijuana exposure and decreased performance on memory, impulse control, problem-solving, quantitative reasoning, verbal development and visual analysis tests; as well as increased performance on attention and global motion perception tests. Limitations included concurrent use of other substances among study participants, potential under-reporting and publication biases, non-generalisable samples and limited published results preventing direct comparison of analyses.
conclusionsThe specific effects of prenatal marijuana exposure remain unclear and warrant further research. The larger number of neuropsychological domains that exhibit decreased versus increased psychological and behavioural functions suggests that exposure to marijuana may be harmful for brain development and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.