ArticleNucleic acids research2019
PopHumanScan: the online catalog of human genome adaptation.
Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations.bioRxiv : the preprint server for biology · 2026Article
- Article
- Genome-wide analysis in human populations reveals mitonuclear disequilibrium in genes related to neurological function.Scientific reports · 2025Article
- Positive Selection Shapes Breast Cancer Tumor Suppressor Genes: Unveiling Insights into BRCA1, BRCA2, and MDC1 Stability.Journal of molecular evolution · 2025Article
- Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency.Nature genetics · 2024Article
- The Role of Selection and Migration in the Evolution of (Auto)Immunity Genes.Journal of molecular evolution · 2024Article
- Evolutionary and functional analyses of LRP5 in archaic and extant modern humans.Human genomics · 2024Article
- Human pangenome analysis of sequences missing from the reference genome reveals their widespread evolutionary, phenotypic, and functional roles.Nucleic acids research · 2024Article
- Putative protective genomic variation in the Lithuanian population.Genetics and molecular biology · 2024Article
- Identifying Genomic Signatures of Positive Selection to Predict Protective Genomic Loci in the Cohort of Lithuanian Clean-Up Workers of the Chornobyl Nuclear Disaster.Current issues in molecular biology · 2023Article
- HaploBlocks: Efficient Detection of Positive Selection in Large Population Genomic Datasets.Molecular biology and evolution · 2023Article
- PopTradeOff: A database for exploring population-specificity of adaptive evolution, disease susceptibility, and drug responsiveness.Computational and structural biotechnology journal · 2023Article
- Article
- Analysis of Common SNPs across Continents Reveals Major Genomic Differences between Human Populations.Genes · 2022Article
- Admixture mapping of anthropometric traits in the Black Women's Health Study: evidence of a shared African ancestry component with birth weight and type 2 diabetes.Journal of human genetics · 2022Article
- PopHumanVar: an interactive application for the functional characterization and prioritization of adaptive genomic variants in humans.Nucleic acids research · 2022Article
- Article
- Evolutionary genetics and acclimatization in nephrology.Nature reviews. Nephrology · 2021Review
- Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals.BMC biology · 2021Article
- Evolutionary forces in diabetes and hypertension pathogenesis in Africans.Human molecular genetics · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the migrations that led humans to colonize Earth, our species has faced frequent adaptive challenges that have left signatures in the landscape of genetic variation and that we can identify in our today's genomes. Here, we (i) perform an outlier approach on eight different population genetic statistics for 22 non-admixed human populations of the Phase III of the 1000 Genomes Project to detect selective sweeps at different historical ages, as well as events of recurrent positive selection in the human lineage; and (ii) create PopHumanScan, an online catalog that compiles and annotates all candidate regions under selection to facilitate their validation and thoroughly analysis. Well-known examples of human genetic adaptation published elsewhere are included in the catalog, as well as hundreds of other attractive candidates that will require further investigation. Designed as a collaborative database, PopHumanScan aims to become a central repository to share information, guide future studies and help advance our understanding of how selection has modeled our genomes as a response to changes in the environment or lifestyle of human populations. PopHumanScan is open and freely available at https://pophumanscan.uab.cat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.