SynthesisMedicine2018
Exercise as an intervention for patients with end-stage liver disease: Systematic review.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- The influence of prehabilitation in patients with liver cirrhosis before liver transplantation: a randomized clinical trial.European journal of physical and rehabilitation medicine · 2024Trial
- The role of rehabilitation across the continuum of liver disease from cirrhosis to transplantation and beyond: A narrative review.PM & R : the journal of injury, function, and rehabilitation · 2025Review
- Mapping of rehabilitation interventions and assessment methods for patients with liver cirrhosis: a scoping review.BMC gastroenterology · 2025Article
- Effect of aerobic exercise on GRP78 and ATF6 expressions in mice with non-alcoholic fatty liver disease.Sports medicine and health science · 2023Article
- Effects of an active lifestyle on the physical frailty of liver transplant candidates.World journal of transplantation · 2022Article
- The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Interrelationship between physical activity and depression in nonalcoholic fatty liver disease.World journal of hepatology · 2022Article
- Clinical practice advice on lifestyle modification in the management of nonalcoholic fatty liver disease in Japan: an expert review.Journal of gastroenterology · 2021Review
- Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease.World journal of gastroenterology · 2020Review
- Impact of cancer rehabilitation on the prognosis of patients with hepatocellular carcinoma.Oncology letters · 2020Article
- Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious etiologies of chronic liver disease often result in cirrhosis. Beside obvious liver-related complications, cirrhosis also leads to loss of muscle mass and decreased exercise capacity. In this study, our aim was to conduct a systematic review of literature to investigate the efficacy of exercise interventions in patients with cirrhosis.
methodPubMed was used to perform the literature search. The mesh terms used were the following: (liver (and) cirrhosis (and) exercise or (exercise therapy)). The following terms were excluded: Non-alcoholic fatty liver disease (NAFLD). The search was limited to the English language and human research. The initial search was conducted on December 6, 2016 and re-reviewed May 2017.
resultsSeven studies met selection criteria. Training interventions ranged between 4 and 14 weeks in duration with an exercise frequency of 3 to 5 days per week. Most studies demonstrated an increase in maximal oxygen consumption using gas exchange techniques. Two of 3 studies demonstrated increased distance covered in the 6-minute walk test. One study showed a clinically significant decrease in hepatic venous pressure gradient, while another showed a transient increase only during exercise. There were no adverse effects of the exercise program reported.
conclusionsExercise in selected patients with cirrhosis can have potential benefit in endurance and functional outcome measures without adverse effect from exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.