Evidence map›Paper›PMID 30334962›Full record

ArticleMedicine2018

The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report.

Radosław Chaber, Artur Gurgul, Grażyna Wróbel, Anna Tomoń, Sylwia Paszek, Natalia Potocka, Olga Haus, Monika Lejman, Kornelia Łach, Tomasz Szmatoła and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

17 authors.

Radosław ChaberDepartment of Pediatric Hematooncology, Faculty of Medicine, University of Rzeszow, Rzeszow.
Artur GurgulNational Research Institute of Animal Production, Laboratory of Genomics, Balice.
Grażyna WróbelDepartment of Paediatric Bone Marrow Transplantation, Oncology and Hematology, Medical University of Wroclaw, Wroclaw.
Anna TomońDepartment of Pediatric Hematooncology, Faculty of Medicine, University of Rzeszow, Rzeszow.
Sylwia PaszekLaboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow.
Natalia PotockaLaboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow.
Olga HausDepartment of Clinical Genetics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Bydgoszcz, Nicolaus Copernicus University in Torun, Torun.
Monika LejmanDepartment of Pediatric, Hematology, Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin.
Kornelia ŁachDepartment of Pediatric Hematooncology, Faculty of Medicine, University of Rzeszow, Rzeszow.
Tomasz SzmatołaNational Research Institute of Animal Production, Laboratory of Genomics, Balice.
Igor JasielczukNational Research Institute of Animal Production, Laboratory of Genomics, Balice.
Blanka RybkaDepartment of Paediatric Bone Marrow Transplantation, Oncology and Hematology, Medical University of Wroclaw, Wroclaw.
Renata Ryczan-KrawczykDepartment of Paediatric Bone Marrow Transplantation, Oncology and Hematology, Medical University of Wroclaw, Wroclaw.
Sylwia StąporDepartment of Hematology, Medical University.
Krzysztof CiebieraInstitute of Informatics, University of Warsaw, Warsaw, Poland.
Christopher J ArthurSchool of Chemistry, University of Bristol, Bristol, United Kingdom.
Izabela ZawlikLaboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleA prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed. PATIENTS CONCERNS: In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase. DIAGNOSES: The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented. INTERVENTIONS AND OUTCOMES: DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples. LESSONS: The biological implication of this observation remains unclear, with many differentially methylated loci involved in many processes like neurogenesis, cell projection organization and adhesion along with leucocyte activation and apoptosis. The prevalence and clinical significance of these methylation changes is unknown but this data indicates that the epigenetic basis of BCP ALL with a prolonged, prodromal phase requires a more detailed assessment.

Indexed as

DNA MethylationProdromal SymptomsAcute DiseaseBone Marrow CellsChildHumansMalePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma

Identifiers

PMID30334962
PMCPMC6211912

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