Evidence map›Paper›PMID 30334752›Full record

ArticleIEEE transactions on medical imaging2019

Path R-CNN for Prostate Cancer Diagnosis and Gleason Grading of Histological Images.

Wenyuan Li, Jiayun Li, Karthik V Sarma, King Chung Ho, Shiwen Shen, Beatrice S Knudsen, Arkadiusz Gertych, Corey W Arnold

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 132 citations in OpenAlex.

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  20. Computational pathology in ovarian cancer.Frontiers in oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenyuan Li
Jiayun Li
Karthik V Sarma
King Chung Ho
Shiwen Shen
Beatrice S Knudsen
Arkadiusz Gertych
Corey W Arnold
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E · 2002 to 2023
$42.6M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Medical Imaging Informatics Training GrantT32EB016640 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEX BUI, William Hsu · 2013 to 2026
$2.3M
Predicting the Presence of Clinically Significant Prostate Cancer using Multiparametric MRI and MR-US Fusion BiopsyR21CA220352 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARNOLD, COREY WELLS · 2018 to 2019
$352k
Development of a Multimodal Deep Learning Model for the Generation of Cancer Probability Maps and Imaging Biomarkers for Prostate Cancer using Multiparametric MRIF30CA210329 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SARMA, KARTHIK VENKATARAMAN · 2016 to 2022
$173k
NCI NIH HHS F30 CA210329NCI NIH HHS P50 CA092131NCI NIH HHS R21 CA220352NIBIB NIH HHS T32 EB016640NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Prostate cancer is the most common and second most deadly form of cancer in men in the United States. The classification of prostate cancers based on Gleason grading using histological images is important in risk assessment and treatment planning for patients. Here, we demonstrate a new region-based convolutional neural network framework for multi-task prediction using an epithelial network head and a grading network head. Compared with a single-task model, our multi-task model can provide complementary contextual information, which contributes to better performance. Our model is achieved a state-of-the-art performance in epithelial cells detection and Gleason grading tasks simultaneously. Using fivefold cross-validation, our model is achieved an epithelial cells detection accuracy of 99.07% with an average area under the curve of 0.998. As for Gleason grading, our model is obtained a mean intersection over union of 79.56% and an overall pixel accuracy of 89.40%.

Indexed as

Neural Networks, ComputerHistocytochemistryHumansImage Interpretation, Computer-AssistedMaleNeoplasm GradingProstateProstatic Neoplasms

Identifiers

PMID30334752
PMCPMC6497079
OpenAlexW2898020899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.