Evidence map›Paper›PMID 30334748›Full record

ArticleIEEE transactions on bio-medical engineering2019

Three-Dimensional Whole Breast Segmentation in Sagittal and Axial Breast MRI With Dense Depth Field Modeling and Localized Self-Adaptation for Chest-Wall Line Detection.

Dong Wei, Susan Weinstein, Meng-Kang Hsieh, Lauren Pantalone, Despina Kontos

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dong Wei
Susan Weinstein
Meng-Kang Hsieh
Lauren Pantalone
Despina Kontos
University of Pennsylvania · US

Funding

Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detectionR01CA207084 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, KONTOS, DESPINA · 2017 to 2021
$3.2M
Cancer imaging phenomics software suite: application to brain and breast cancerU24CA189523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, KONTOS, DESPINA · 2015 to 2019
$3.2M
Radiogenomic Biomarkers of Breast Cancer RecurrenceR01CA223816 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHODOSH, LEWIS A, KONTOS, DESPINA · 2018 to 2022
$3.1M
Multi-parametric 4-D Imaging Biomarkers for Neoadjuvant Treatment ResponseR01CA197000 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2016 to 2020
$2.4M
MRI Background Parenchymal Enhancement as a Risk Factor for Breast CancerR01CA183086 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BERNSTEIN, JONINE L., PIKE, MALCOLM C · 2014 to 2016
$2.1M
Biomedical Image Computing and Informatics ClusterS10OD023495 · OD · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2017
$1.9M
NCI NIH HHS R01 CA183086NCI NIH HHS R01 CA197000NCI NIH HHS R01 CA207084NCI NIH HHS R01 CA223816NCI NIH HHS U24 CA189523NIH HHS S10 OD023495
6 · The paper itself

Abstract

objectiveWhole breast segmentation is an essential task in quantitative analysis of breast MRI for cancer risk assessment. It is challenging, mainly, because the chest-wall line (CWL) can be very difficult to locate due to its spatially varying appearance-caused by both nature and imaging artifacts-and neighboring distracting structures. This paper proposes an automatic three-dimensional (3-D) segmentation method, termed DeepSeA, of whole breast for breast MRI.

methodsDeepSeA distinguishes itself from previous methods in three aspects. First, it reformulates the challenging problem of CWL localization as an equivalent problem that optimizes a smooth depth field and so fully utilizes the CWL's 3-D continuity. Second, it employs a localized self-adapting algorithm to adjust to the CWL's spatial variation. Third, it applies to breast MRI data in both sagittal and axial orientations equally well without training.

resultsA representative set of 99 breast MRI scans with varying imaging protocols is used for evaluation. Experimental results with expert-outlined reference standard show that DeepSeA can segment breasts accurately: the average Dice similarity coefficients, sensitivity, specificity, and CWL deviation error are 96.04%, 97.27%, 98.77%, and 1.63 mm, respectively. In addition, the configuration of DeepSeA is generalized based on experimental findings, for application to broad prospective data.

conclusionA fully automatic method-DeepSeA-for whole breast segmentation in sagittal and axial breast MRI is reported. SIGNIFICANCE: DeepSeA can facilitate cancer risk assessment with breast MRI.

Indexed as

AdultAlgorithmsBreastBreast NeoplasmsFemaleHumansImaging, Three-DimensionalMiddle AgedSensitivity and SpecificityThoracic WallYoung Adult

Identifiers

PMID30334748
PMCPMC6684022
OpenAlexW2897432176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.