ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Non-invasive monitoring of longitudinal changes in cerebral hemodynamics in acute ischemic stroke using BOLD signal delay.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Progressive microvascular failure in acute ischemic stroke: A systematic review, meta-analysis, and time-course analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Pooled it
- Evaluation of cerebrovascular reactivity impairment using resting-state BOLD MRI in symptomatic patients with unilateral intracranial artery occlusion.Cerebral circulation - cognition and behavior · 2026Article
- Associations between cerebral blood transit time, amyloid-β pathology and cognitive decline in non-demented older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A molecular brain atlas reveals cellular shifts during the repair phase of stroke.Journal of neuroinflammation · 2025Article
- Reshaped functional connectivity gradients in acute ischemic stroke.NeuroImage. Clinical · 2025Article
- Effect of inflammation on neurovascular coupling, microperfusion, and clinical outcomes in ischemic stroke patients: a case series report.Frontiers in medicine · 2025Article
- Altered brain perfusion and oxygen levels relate to sleepiness and attention in post-COVID syndrome.Annals of clinical and translational neurology · 2024Article
- Functional connectivity-hemodynamic (un)coupling changes in chronic mild brain injury are associated with mental health and neurocognitive indices: a resting state fMRI study.Neuroradiology · 2024Article
- Article
- Reproducibility of cerebral perfusion measurements using BOLD delay.Human brain mapping · 2023Article
- Article
- Chronic remote ischemic conditioning for symptomatic internal carotid or middle cerebral artery occlusion: A prospective cohort study.CNS neuroscience & therapeutics · 2022Article
- Potential nanotherapeutic strategies for perioperative stroke.CNS neuroscience & therapeutics · 2022Review
- A novel approach for assessing hypoperfusion in stroke using spatial independent component analysis of resting-state fMRI.Human brain mapping · 2021Article
- Total perfusion-diffusion mismatch detected using resting-state functional MRI.BJR case reports · 2021Article
- A precision medicine framework for personalized simulation of hemodynamics in cerebrovascular disease.Biomedical engineering online · 2021Article
- Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study.Lupus science & medicine · 2021Article
- Monitoring and Prognostic Analysis of Severe Cerebrovascular Diseases Based on Multi-Scale Dynamic Brain Imaging.Frontiers in neuroscience · 2021Article
- Evidence of Age-Related Hemodynamic and Functional Connectivity Impairment: A Resting State fMRI Study.Frontiers in neurology · 2021Article
- The Effect of Scan Length on the Assessment of BOLD Delay in Ischemic Stroke.Frontiers in neurology · 2020Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Relative delays in blood-oxygen-level-dependent (BOLD) signal oscillations can be used to assess cerebral perfusion without using contrast agents. However, little is currently known about the utility of this method in detecting clinically relevant perfusion changes over time. We investigated the relationship between longitudinal BOLD delay changes, vessel recanalization, and reperfusion in 15 acute stroke patients with vessel occlusion examined within 24 h of symptom onset (D0) and one day later (D1). We created BOLD delay maps using time shift analysis of resting-state functional MRI data and quantified perfusion lesion volume changes (using the D1/D0 volume ratio) and severity changes (using a linear mixed model) over time. Between baseline and follow-up, BOLD delay lesions shrank (median D1/D0 ratio = 0.2, IQR = 0.03-0.7) and BOLD delay severity decreased (b = -4.4 s) in patients with recanalization, whereas they grew (median D1/D0 ratio = 1.47, IQR = 1.1-1.7) and became more severe (b = 4.3 s) in patients with persistent vessel occlusion. Clinically relevant changes in cerebral perfusion in early stroke can be detected using BOLD delay, making this non-invasive method a promising option for detecting tissue at risk of infarction and monitoring stroke patients following recanalization therapy.
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