Evidence map›Paper›PMID 30334618›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2019

Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non-small-cell lung cancer.

Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama and 8 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 12 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 12 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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  5. Multimodal interventions for cachexia management.The Cochrane database of systematic reviews · 2025
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  13. Exercise as supportive care in advanced cancer-related weight loss: a feasibility study comparing patients with and without severe weight loss.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  18. Feasibility and safety of exercise during chemotherapy in people with gastrointestinal cancers: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 2 countries.

Tateaki NaitoDivision of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.ORCID 0000-0003-4047-2929
Shuichi MitsunagaDepartment of Hepatobilliary and Pancreatic Oncology, National Cancer Center Hospital East, Chiba, Japan.
Satoru MiuraDepartment of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan.
Noriatsu TatematsuDepartment of Rehabilitation Medicine, National Cancer Center Hospital East, Chiba, Japan.
Toshimi InanoDivision of Nutrition, Shizuoka Cancer Center, Shizuoka, Japan.
Takako MouriDepartment of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tetsuya TsujiDivision of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
Takashi HigashiguchiDepartment of Surgery and Palliative Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Akio InuiPharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Taro OkayamaDivision of Rehabilitation Medicine, Shizuoka Cancer Center, Shizuoka, Japan.
Teiko YamaguchiDivision of Nutrition, Kyushu University Hospital, Kyushu, Japan.
Ayumu MorikawaDivision of Nursing, Shizuoka Cancer Center, Shizuoka, Japan.
Naoharu MoriPalliative Care Center, Aichi Medical University, Aichi, Japan.
Toshiaki TakahashiDivision of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Florian StrasserOncological Palliative Medicine, Clinic Oncology and Hematology, Department of Internal Medicine, Cantonal Hospital, St. Gallen, Switzerland.
Katsuhiro OmaeDepartment of Clinical Biostatistics, Kyoto University, Kyoto, Japan.
Keita MoriDivision of Clinical Research Center, Shizuoka Cancer Center, Shizuoka, Japan.
Koichi TakayamaDepartment of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shizuoka Cancer Center · JPKyoto Prefectural University of Medicine · JPNational Cancer Center Hospital East · JPAichi Medical University · JPFujita Health University · JPKagoshima University · JPKeio University · JPKyoto University · JPKyushu University Hospital · JPNiigata Cancer Center Hospital · JPUniversity of St.Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCombinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme.

methodsThis was a multicentre prospective single-arm study. We recruited 30 of 46 screened patients aged ≥70 years scheduled to receive first-line chemotherapy for newly diagnosed, advanced pancreatic, or non-small-cell lung cancer. Physical activity was measured using pedometers/accelerometer (Lifecorder

resultsThe median patient age was 75 years (range, 70-84). Twelve patients (40%) were cachectic at baseline. Twenty-nine patients attended ≥4 of the six planned sessions (96.7%, 95% confidence interval, 83.3 to 99.4). One patient dropped out due to deteriorating health status. The median proportion of days of compliance with supplement consumption and exercise performance were 99% and 91%, respectively. Adverse events possibly related to the NEXTAC programme were observed in five patients and included muscle pain (Grade 1 in two patients), arthralgia (Grade 1 in one patient), dyspnoea on exertion (Grade 1 in one patient), and plantar aponeurositis (Grade 1 in one patient).

conclusionsThe early induction of multimodal interventions showed excellent compliance and safety in elderly patients with newly diagnosed pancreatic and non-small-cell lung cancer receiving concurrent chemotherapy. We are now conducting a randomized phase II study to measure the impact of these interventions on functional prognosis.

Indexed as

Exercise TherapyNutrition TherapyAgedAged, 80 and overCarcinoma, Non-Small-Cell LungFeasibility StudiesFemaleHumansLung NeoplasmsMaleMuscle, SkeletalNutrition AssessmentPancreatic NeoplasmsPhysical FitnessCancer cachexiaElderlyMultimodal interventionNon-small-cell lung cancerPancreatic cancerPhysical activity

Identifiers

PMID30334618
PMCPMC6438328
OpenAlexW2897698573

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.