ArticleChinese medical journal2018
Applications of Isolated-Check Visual Evoked Potential in Early Stage of Open-Angle Glaucoma Patients.
Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.
- Diagnostic accuracy of isolated-check visual evoked potentials for glaucoma: a systematic review and meta-analysis.BMC ophthalmology · 2025Pooled it
- Glaucoma Classification Through SSVEP-Derived ON- and OFF-Pathway Features.Translational vision science & technology · 2026Article
- Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study.BMJ open ophthalmology · 2024Article
- Utility of isolated-check visual evoked potential technique in dysthyroid optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Diagnostic Capability of Isolated-Check Visual Evoked Potential for Early to Moderate Primary Open-Angle Glaucoma.Life (Basel, Switzerland) · 2023Article
- Isolated-check visual evoked potential: a more sensitive tool to detect traumatic optic neuropathy after orbital fracture.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Applications of dynamic visual acuity test in clinical ophthalmology.International journal of ophthalmology · 2021Review
- Applications of the isolated-check visual evoked potential in primary open angle glaucoma with or without high myopia.International journal of ophthalmology · 2021Article
- Discovery and clinical translation of novel glaucoma biomarkers.Progress in retinal and eye research · 2021Review
- Diagnostic Performance of a Handheld Electroretinography Test for Glaucoma.Ophthalmology scienceArticle
- Visual evoked potential in the early diagnosis of glaucoma. Literature review.Romanian journal of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStandard automated perimetry does not sufficiently detect early open-angle glaucoma (OAG) in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential (icVEP) could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors.
methodsThis was a cross-sectional study. Thirty-seven OAG patients with early-stage visual field loss (mean deviation ≥ -6.00 dB) detected by the Humphrey Field Analyzer (30-2 SITA program) and 26 controls were included in this study. Optical coherence tomography (OCT) was used to detect retinal nerve fiber layer (RNFL) defects. The icVEP preferentially evaluates the magnocellular-ON pathway. VEPs were recorded and signal-to-noise ratios (SNRs) were derived based on multivariate analysis. Eyes that yielded an SNR ≤1 were considered abnormal. Receiver operating characteristic (ROC) curve analysis was used to estimate the accuracy of group classification. Correlations between SNRs and related factors were analyzed.
resultsBased on an SNR criterion of 1, the icVEP had a sensitivity of 62.2% and a specificity of 92.3% for diagnosing early-stage OAG with 74.6% classification accuracy. The ROC curve analysis, however, suggested that an SNR criterion of 0.93 would produce the highest classification accuracy (77.3%). Both RNFL thinning in the temporal superior quadrant on OCT and number of abnormal test points in the central 11° visual field (pattern deviation, P < 0.5%) significantly correlated with the SNR (P < 0.05).
conclusionsThe icVEP detected visual function abnormalities in approximately 3/5 of eyes with early-stage OAG with greater than 90% specificity. SNR correlated with both a decrease in RNFL thickness and severity of central visual field loss.
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