ArticleKorean circulation journal2018
Exercise induced Right Ventricular Fibrosis is Associated with Myocardial Damage and Inflammation.
Article in Korean circulation journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Identification and Verification of Potential Markers Related to Myocardial Fibrosis by Bioinformatics Analysis.Biochemical genetics · 2025Review
- The Role of Selected Myokines in the Development of Cardiovascular Diseases, and Their Involvement in Developing Heart Failure in Rheumatoid Arthritis Patients.International journal of molecular sciences · 2025Review
- Housing temperature influences exercise-induced glucose regulation and expression of exerkines in mice.Experimental physiology · 2025Article
- Chronic moderate‑intensity exercise can induce physiological hypertrophy in aged cardiomyocytes through autophagy, with minimal Yap/Taz involvement.Biomedical reports · 2025Article
- SDF-1-edited human amniotic mesenchymal stem cells stimulate angiogenesis in treating hindlimb ischaemia.Journal of cellular and molecular medicine · 2022Article
- Influences of Long-Term Exercise and High-Fat Diet on Age-Related Telomere Shortening in Rats.Cells · 2022Article
- Potential Long-Term Health Problems Associated with Ultra-Endurance Running: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2022Review
- The effects of long-term moderate exercise and Western-type diet on oxidative/nitrosative stress, serum lipids and cytokines in female Sprague Dawley rats.European journal of nutrition · 2022Article
- Optimization of different intensities of exercise preconditioning in protecting exhausted exercise induced heart injury in rats.Sports medicine and health science · 2021Article
- Sex Differences in Cardiac Remodeling in Athletes: Men on the Left, Women on the Right?Korean circulation journal · 2021Article
- The effects of endurance exercise on the heart: panacea or poison?Nature reviews. Cardiology · 2020Review
- Prolonged Intensive Exercise: When the Right Ventricle Goes Wrong.Korean circulation journal · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
objectivesIntense exercise (IE) induced myocardial fibrosis (MF) showed contradictory findings in human studies, making the relationship between IE and the development of MF unclear. This study aims to demonstrate exercise induced MF is associated with cardiac damage, and inflammation is essential to the development of exercise induced MF.
methodsSprague-Dawley rats were submitted to daily 60-minutes treadmill exercise sessions at vigorous or moderate intensity, with 8-, 12-, and 16-week durations; time-matched sedentary rats served as controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum cardiac troponin I (cTnI) concentration. After completion of the exercise protocol rats were euthanized. Biventricular morphology, ultrastructure, and collagen deposition were then examined. Protein expression of interleukin (IL)-1β and monocyte chemotactic protein (MCP)-1 was evaluated in both ventricles.
resultsAfter IE, right but not left ventricle (LV) MF occurred. Serum cTnI levels increased and right ventricular damage was observed at the ultrastructure level in rats that were subjected to long-term IE. Leukocyte infiltration into the right ventricle (RV) rather than LV was observed after long-term IE. Long-term IE also increased protein expression of pro-inflammation factors including IL-1β and MCP-1 in the RV.
conclusionsRight ventricular damage induced by long-term IE is pathological and the following inflammatory response is essential to the development of exercise induced MF.
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