Evidence map›Paper›PMID 30334271›Full record

ArticleBritish journal of clinical pharmacology2019

CYP2E1 activity and children with obesity: possible confounding factors.

Hardeep Kaur, Phulen Sarma, Ajay Prakash, Bikash Medhi

Abstract readLetterComment
In one paragraph

Article in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. CYP2E1 activity and children with obesity: possible confounding factors.British journal of clinical pharmacology · 2019
    Article
  2. Obesity-induced CYP2E1 activity in children.British journal of clinical pharmacology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Hardeep KaurDepartment of Pharmacology, PGIMER, Chandigarh, India.
Phulen SarmaDepartment of Pharmacology, PGIMER, Chandigarh, India.
Ajay PrakashDepartment of Pharmacology, PGIMER, Chandigarh, India.
Bikash MedhiDepartment of Pharmacology, PGIMER, Chandigarh, India.ORCID 0000-0002-4017-641X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lots of factors can influence CYP2E1 activities, e.g. thyroid status, different types of anaemia (fanconi anaemia and sideroblastic anaemia), etc. Alcohol is a known inducer of CYP2E1, therefore a justifiable duration of abstinence is required before the subjects are enrolled into a study for normalization of CYP2E1 activity. In this letter we address these confounding factors and their role in CYP2E1 activity.

Indexed as

ChlorzoxazoneCytochrome P-450 CYP2E1ChildEthanolHumansObesityChlorzoxazoneCytochrome P-450 CYP2E1Ethanol

Identifiers

PMID30334271
PMCPMC6339960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.