Evidence map›Paper›PMID 30334228›Full record

ReviewThe international journal of cardiovascular imaging2019

Moving into the next era of PET myocardial perfusion imaging: introduction of novel

Rudolf A Werner, Xinyu Chen, Steven P Rowe, Constantin Lapa, Mehrbod S Javadi, Takahiro Higuchi

Open access · hybridAbstract readReview
In one paragraph

Review in The international journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Easy and versatile preparation ofEJNMMI radiopharmacy and chemistry · 2026
    Article
  2. American journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Biodistribution, Safety Profile, and Radiation Dosimetry of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Review
  5. Recent Progress in Myocardial Perfusion Imaging Techniques.Nuclear medicine and molecular imaging · 2024
    Review
  6. Article
  7. Article
  8. Preliminary Evaluation ofMolecular imaging and biology · 2023
    Article
  9. Myocardial Functional Imaging in Pediatric Nuclear Cardiology.Journal of cardiovascular development and disease · 2023
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Automated Synthesis ofFrontiers in chemistry · 2022
    Article
  15. Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([International journal of molecular sciences · 2021
    Article
  16. Article
  17. Review
  18. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  19. Myocardial-coronary fusion imaging with positron emission tomography and computed tomography: Benchmarking and slingshotting.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rudolf A WernerDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xinyu ChenDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Steven P RoweDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Constantin LapaDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Mehrbod S JavadiDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Takahiro HiguchiDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany. thiguchi@me.com.
University of Würzburg · DEJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Deutsche Forschungsgemeinschaft 1516/2-1Deutsche Forschungsgemeinschaft 1789/3-3H2020 European Research Council 701983
6 · The paper itself

Abstract

The heart failure epidemic continues to rise with coronary artery disease as one of its main causes. Novel concepts for risk stratification to guide the referring cardiologist towards revascularization procedures are of significant value. Myocardial perfusion imaging using single-photon emission computed tomography (SPECT) agents has demonstrated high accuracy for the detection of clinically relevant stenoses. With positron emission tomography (PET) becoming more widely available, mainly due to its diagnostic performance in oncology, perfusion imaging with that modality is more practical than in the past and overcomes existing limitations of SPECT MPI. Advantages of PET include more reliable quantification of absolute myocardial blood flow, the routine use of computed tomography for attenuation correction, a higher spatiotemporal resolution and a higher count sensitivity. Current PET radiotracers such as rubidium-82 (half-life, 76 s), oxygen-15 water (2 min) or nitrogen-13 ammonia (10 min) are labeled with radionuclides with very short half-lives, necessitating that stress imaging is performed under pharmacological vasodilator stress instead of exercise testing. However, with the introduction of novel

Indexed as

Coronary CirculationAnimalsCoronary Artery DiseaseCoronary VesselsHumansMyocardial Perfusion ImagingOrganophosphorus CompoundsPositron-Emission TomographyPredictive Value of TestsPyridazinesRadiopharmaceuticals18F-fluorobenzyl triphenyl phosphoniumBMS 747158-02Organophosphorus CompoundsPyridazinesRadiopharmaceuticals18F-FBnTP18F-flurpiridazCoronary artery diseaseMyocardial perfusion imagingPositron emission tomographyPrecision medicine

Identifiers

PMID30334228
PMCPMC6454078
OpenAlexW2897109269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.