Evidence map›Paper›PMID 30334131›Full record

ArticleJournal of assisted reproduction and genetics2018

Decision-making surrounding the use of preimplantation genetic testing for aneuploidy reveals misunderstanding regarding its benefit.

Molly M Quinn, Flor Juarez-Hernandez, Molly Dunn, Richard Jason Okamura, Marcelle I Cedars, Mitchell P Rosen

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06018454 (Preimplantation Genetic Testing for Aneuploidy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06018454 nacompletednot on this mapstarted 2022, after this paper: background citation

Preimplantation Genetic Testing for Aneuploidy (PGT-A) Counseling for Patients Undergoing in Vitro Fertilization (IVF)

TypeinterventionalSponsorEyup Hakan DuranRan2022 to 2024Enrolled213ConditionsPatient EducationArmsHandout on PGT-A, Handout on PGT-A and genetic counseling
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Molly M QuinnDepartment of Obstetrics, Gynecology and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, University of California San Francisco School of Medicine, 550 16th Street, 7th Floor, San Francisco, CA, 94158-2519, USA. quinn.molly@gmail.com.ORCID http://orcid.org/0000-0002-6787-6539
Flor Juarez-HernandezDepartment of Obstetrics, Gynecology and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, University of California San Francisco School of Medicine, 550 16th Street, 7th Floor, San Francisco, CA, 94158-2519, USA.
Molly DunnDepartment of Obstetrics, Gynecology and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, University of California San Francisco School of Medicine, 550 16th Street, 7th Floor, San Francisco, CA, 94158-2519, USA.
Richard Jason OkamuraDepartment of Obstetrics, Gynecology and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, University of California San Francisco School of Medicine, 550 16th Street, 7th Floor, San Francisco, CA, 94158-2519, USA.
Marcelle I CedarsDepartment of Obstetrics, Gynecology and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, University of California San Francisco School of Medicine, 550 16th Street, 7th Floor, San Francisco, CA, 94158-2519, USA.
Mitchell P RosenDepartment of Obstetrics, Gynecology and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, University of California San Francisco School of Medicine, 550 16th Street, 7th Floor, San Francisco, CA, 94158-2519, USA.
University of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to explore how patients make decisions regarding use of preimplantation genetic testing for aneuploidy (PGT-A) for in vitro fertilization (IVF).

methodsThis is a cross-sectional survey at an academic medical center. Three hundred subjects initiating an IVF cycle over 8 weeks were asked to complete a validated survey to determine how they decided whether or not to pursue PGT-A. All patients were previously counseled that the primary goal of PGT-A is to maximize pregnancy rates per embryo transfer. Survey responses were compared between those who elected PGT-A and those who did not with a chi-squared or t test.

resultsOf 191 subjects who completed the survey, 117 (61%) planned PGT-A, while 74 (39%) did not. Among those who decided to undergo PGT-A, 56% stated their primary reason was to have a healthy baby, while 18% chose PGT-A to reduce the incidence of birth defects, and 16% aimed to decrease the risk of miscarriage. Patients who decided not to pursue PGT-A stated they prioritized avoiding the scenario in which they might have no embryos to transfer (36%) or reducing cost (31%). Both groups rated physicians as the single most important source of information in their decision-making (56% vs 68%, p = NS).

conclusionsPatients who chose to undergo PGT-A have different priorities from those who do not. Many patients planning PGT-A do so for reasons that are not evidence-based. While patients cite physicians as their primary source of information in the decision-making process, rationales for selecting PGT-A are inconsistent with physician counseling.

Indexed as

Fertilization in VitroGenetic TestingAneuploidyDecision MakingEmbryo TransferFemaleHumansPregnancyPregnancy RatePreimplantation DiagnosisAneuploidy screeningIn vitro fertilization (IVF)Medical decision-makingPatient counselingPatient perspectivesPreimplantation genetic testing (PGT)

Identifiers

PMID30334131
PMCPMC6289916
OpenAlexW2897096141

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.