ReviewTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2019
A mutation in class III homeodomain-leucine zipper (HD-ZIP III) transcription factor results in curly leaf (cul) in cucumber (Cucumis sativus L.).
Review in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Machine learning-guided leaf margin classification and discovery that BcPHB promoter selection rewires a BcPHB-BcLMI1 module to shape leaf margins in Brassica campestris.Molecular horticulture · 2026Article
- Genetic Mapping and Functional Characterisation of GhCUP Regulating Leaf Curling in Cotton.Plant biotechnology journal · 2026Article
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- Homeodomain leucine zipper protein controls the lobed leaf formation by modulating auxin distribution in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Evolution of HD-ZIP transcription factors and their function in cabbage leafy head formation.Frontiers in plant science · 2025Article
- BrBCAT1 mutation resulted in deficiency of epicuticular wax crystal in Chinese cabbage.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A mutation in CsGME encoding GDP-mannose 3,5-epimerase results in little and wrinkled leaf in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Article
- Fine Mapping of a Pleiotropic Locus (International journal of molecular sciences · 2023Article
- Exploring the Agrobacterium-mediated transformation with CRISPR/Cas9 in cucumber (Cucumis sativus L.).Molecular biology reports · 2022Article
- Expression Profiling and MicroRNA Regulatory Networks of Homeobox Family Genes in SugarcaneInternational journal of molecular sciences · 2022Article
- Genetic and transcriptomic dissection of an artificially induced paired spikelets mutant of wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Article
- Morphological Characterization and Integrated Transcriptome and Proteome Analysis ofInternational journal of molecular sciences · 2022Article
- The sly-miR166-SlyHB module acts as a susceptibility factor during ToLCNDV infection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- The SlHB8 acts as a negative regulator in tapetum development and pollen wall formation in Tomato.Horticulture research · 2022Article
- Construction of a density mutant collection in bitter gourdFrontiers in plant science · 2022Article
- Identification and Fine Mapping of a Locus Related to Leaf Up-Curling Trait (Bnuc3) inInternational journal of molecular sciences · 2021Article
- CsKTN1 for a katanin p60 subunit is associated with the regulation of fruit elongation in cucumber (Cucumis sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genetic regulation of shoot architecture in cucumber.Horticulture research · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
key messageWe identified two curly-leaf (cul) mutants in cucumber. Map-based cloning revealed that both mutants are due to allelic mutations in the CsPHB gene, a homolog of the Arabidopsis PHABULOSA which encodes a class III homeodomain-leucine zipper (HD-ZIP III) transcription factor. Leaf rolling is an important agronomic trait in crop breeding. Moderate leaf rolling minimizes shadowing between leaves, leading to improved photosynthetic efficiency. Although a number of genes controlling rolled leaf have been identified from rice and other plant species, none have been mapped or cloned in cucurbit crops. In this study, we identified and characterized two curly leaf (cul) mutants, cul-1 and cul-2 in cucumber. With map-based cloning, we show that cul-1 and cul-2 are allelic mutations and CsPHB (Csa6G525430) was the candidate gene for both mutants. The CsPHB gene encoded a class III homeodomain-leucine zipper (HD-ZIP III) transcription factor. A single non-synonymous mutation in the fourth and fifth exons of the CsPHB was responsible for the cul-1 and cul-2 mutant phenotypes, respectively. The single-nucleotide substitutions in cul-1 and cul-2 were both located in cs-miRNA165/166 complementary sites of CsPHB. The expression level of CsPHB gene in multiple organs of cul-1 and cul-2 mutants was higher than that in the wild type, while the expression of cs-miRNA165/166 in the two genotypes showed the opposite trend. We speculate that disruption of the binding between the mutant allele of CsPHB and cs-miRNA165/166 leads to the curly-leaf phenotype. This is the first report to clone and characterize the CsPHB gene in the family Cucurbitaceae. Taken together, these results support CsPHB as an important player in the modulation of leaf shape development in cucumber.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.