ArticleScience advances2018
Wide-field multiphoton imaging through scattering media without correction.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.ACS photonics · 2025Review
- Deep compressed multichannel adaptive optics scanning light ophthalmoscope.Science advances · 2025Article
- Scattering correction through Fourier-domain intensity coupling in two-photon microscopy (2P-FOCUS).Photonics research · 2025Article
- Widefield ultra-high-density optical breast tomography system supplementing x-ray mammography.Scientific reports · 2025Article
- Large-scale scattering-augmented optical encryption.Nature communications · 2024Article
- 3D super-resolution optical fluctuation imaging with temporal focusing two-photon excitation.Biomedical optics express · 2024Article
- Multiline orthogonal scanning temporal focusing (mosTF) microscopy for scattering reduction in in vivo brain imaging.Scientific reports · 2024Article
- Multiline Orthogonal Scanning Temporal Focusing (mosTF) Microscopy for Scattering Reduction in High-speedResearch square · 2023Article
- DEEP-squared: deep learning powered De-scattering with Excitation Patterning.Light, science & applications · 2023Article
- Optical single-pixel volumetric imaging by three-dimensional light-field illumination.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- De-scattering Deep Neural Network Enables Fast Imaging of Spines through Scattering Media by Temporal Focusing Microscopy.Research square · 2023Article
- Three-dimensional bi-functional refractive index and fluorescence microscopy (BRIEF).Biomedical optics express · 2022Article
- Image improvement of temporal focusing multiphoton microscopy via superior spatial modulation excitation and Hilbert-Huang transform decomposition.Scientific reports · 2022Article
- Remote Focusing in a Temporal Focusing Microscope.OSA continuum · 2021Article
- Single pixel imaging at megahertz switching rates via cyclic Hadamard masks.Nature communications · 2021Article
- De-scattering with Excitation Patterning enables rapid wide-field imaging through scattering media.Science advances · 2021Article
- Single-pixel imaging of dynamic objects using multi-frame motion estimation.Scientific reports · 2021Article
- In situ measurement of the isoplanatic patch for imaging through intact bone.Journal of biophotonics · 2021Article
- Scanless two-photon excitation with temporal focusing.Nature methods · 2020Review
- Control of the temporal and polarization response of a multimode fiber.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical approaches to fluorescent, spectroscopic, and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances across the biomedical sciences. While the advances have been startling, the key unmet challenge to date in all forms of optical imaging is to penetrate deeper. A number of schemes implement aberration correction or the use of complex photonics to address this need. In contrast, we approach this challenge by implementing a scheme that requires no a priori information about the medium nor its properties. Exploiting temporal focusing and single-pixel detection in our innovative scheme, we obtain wide-field two-photon images through various turbid media including a scattering phantom and tissue reaching a depth of up to seven scattering mean free path lengths. Our results show that it competes favorably with standard point-scanning two-photon imaging, with up to a fivefold improvement in signal-to-background ratio while showing significantly lower photobleaching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.