Evidence map›Paper›PMID 30333986›Full record

ArticleOptica2017

Biomaterial microlasers implantable in the cornea, skin, and blood.

Matjaž Humar, Anja Dobravec, Xiangwei Zhao, Seok Hyun Yun

Open access · goldAbstract read
In one paragraph

Article in Optica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Biomedical optics express · 2022
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Non-obstructive intracellular nanolasers.Nature communications · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Matjaž HumarCondensed Matter Department, J. Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Anja DobravecCondensed Matter Department, J. Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Xiangwei ZhaoState Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.
Seok Hyun YunWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne St. UP-5, Cambridge, Massachusetts 02139, USA.
Jožef Stefan Institute · SIMassachusetts General Hospital · USState Key Laboratory of Digital Medical EngineeringUniversity of Ljubljana · SI

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Massive wavelength-division multiplexing and imaging with laser particlesDP1EB024242 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2016 to 2020
$5.8M
NIBIB NIH HHS DP1 EB024242NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

Stand-alone laser particles that are implantable into biological tissues have potential to enable novel optical imaging, diagnosis and therapy. Here we demonstrate several types of biocompatible microlasers and their lasing action within biological systems. Dye-doped polystyrene beads were embedded in the cornea and optically pumped to generate narrowband emission. We fabricated microbeads with poly(lactic-co-glycolic acid) and poly(lactic acid)-substances approved for medical use-and demonstrate lasing from within tissues and whole blood. Furthermore, we demonstrate biocompatible cholesterol-derivative microdroplet lasers via self-assembly to an onion-like radially-resonant photonic crystal structure.

Identifiers

PMID30333986
PMCPMC6188636
OpenAlexW2753738774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.