ReviewFrontiers in oncology2018
Hypofractionated Radiation Therapy for Large Brain Metastases.
Review in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Single- and hypofractionated stereotactic radiosurgery for large (> 2 cm) brain metastases: a systematic review.Journal of neuro-oncology · 2021Pooled it
- Dose selection and clinical decision-making after Gamma Knife surgery for large brain metastases: implications for early identification of true progression.Journal of neuro-oncology · 2026Observational
- Longitudinal remodeling of brain metastasis resection cavities after adjuvant gamma knife radiosurgery.Journal of neuro-oncology · 2026Article
- Management of critically located brain metastases in patients with precluded survival using customised double-dose prescription-based, adaptive accelerated staged radiosurgery: a long-term retrospective analysis.Radiation oncology (London, England) · 2025Article
- Efficacy and safety of stereotactic radiosurgery for large cystic brain metastases: a comparison with and without cyst aspiration via Ommaya reservoir.Neurosurgical review · 2025Article
- Limitations of outcome prediction based on interfractional volume changes of large (≥ 10cmActa neurochirurgica · 2024Article
- Growth speed of large brain metastases between diagnostic and radiosurgical planning MRI and predictors of rapid tumor growth.Japanese journal of radiology · 2024Article
- Fractionated versus staged gamma knife radiosurgery for mid-to-large brain metastases: a propensity score-matched analysis.Journal of neuro-oncology · 2023Article
- Stereotactic radiosurgery for patients with brain metastases from gastroesophageal cancers.Journal of neuro-oncology · 2023Article
- Let's make size not matter: tumor control and toxicity outcomes of hypofractionated Gamma Knife radiosurgery for large brain metastases.Journal of neuro-oncology · 2023Article
- Immune microenvironment remodeling after radiation of a progressing brain metastasis.Cell reports. Medicine · 2023Article
- Efficacy and Safety of Radiotherapy Combined with Pyrotinib in the Treatment of HER2-Positive Breast Cancer with Brain Metastases.Breast cancer (Dove Medical Press) · 2023Article
- Assessment of intra-fraction motion during frameless image guided Gamma Knife stereotactic radiosurgery.Physics and imaging in radiation oncology · 2023Article
- Revisiting the Role of Surgical Resection for Brain Metastasis.Brain tumor research and treatment · 2023Review
- Feasibility of linac-based fractionated stereotactic radiotherapy and stereotactic radiosurgery for patients with up to ten brain metastases.Radiation oncology (London, England) · 2022Article
- Brain metastases: An update on the multi-disciplinary approach of clinical management.Neuro-Chirurgie · 2022Review
- Management Strategies for Large Brain Metastases.Frontiers in oncology · 2022Review
- Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors.Clinical & experimental metastasis · 2021Article
- Review
- Risk of radiation necrosis after hypofractionated stereotactic radiotherapy (HFSRT) for brain metastases: a single center retrospective study.Journal of neuro-oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single fraction radiosurgery (SRS) treatment is an effective and recognized alternative to whole brain radiation for brain metastasis. However, SRS is not always possible, especially in tumors of a larger diameter where the administration of high dose in a single fraction is limited by the possibility of acute and late side effects and the dose to the surrounding organs at risk. Hypofractionated radiation therapy allows the delivery of high doses of radiation per fraction while minimizing adverse events, all the while maintaining good local control of lesions. The optimal dose fractionation has however not been established. This overwiew presents available evidence and rationale supporting usage of hypofractionated radiation therapy in the treatment of large brain metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.