Evidence map›Paper›PMID 30333875›Full record

ArticleOncology letters2018

Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF-κB/caspase-3 signaling pathways.

Xin Zhang, Ping Fang, Zigang Zhao, Xiangyu Ding, Fang Xie, Yilin Wang, Chengxin Li

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Efficacy and Safety ofIntegrative cancer therapies
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xin ZhangDepartment of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Ping FangDepartment of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Zigang ZhaoDepartment of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Xiangyu DingDepartment of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Fang XieDepartment of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Yilin WangDepartment of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Chengxin LiDepartment of Dermatology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China.
Chinese People's Liberation Army · CNPeople's Liberation Army No. 150 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is highly malignant, particularly prone to metastasizing to the skin. The incidence of melanoma varies markedly between countries, and is relatively low in China. The aim of the present study was to investigate the antitumorigenic effect of damnacanthal on melanoma cells, and its molecular mechanism. MUM-2B cells were treated with 0-20 µM damnacanthal for 12, 24 and 48 h.

Indexed as

damnacanthalmelanomanuclear factor-κBtumor protein p53

Identifiers

PMID30333875
PMCPMC6176422
OpenAlexW2889492515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.