Evidence map›Paper›PMID 30333823›Full record

ArticleFrontiers in immunology2018

Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against

Khalil Farhat, Gwennaëlle Bodart, Chantal Charlet-Renard, Christophe J Desmet, Michel Moutschen, Yves Beguin, Frédéric Baron, Pierrette Melin, Pascale Quatresooz, Anne-Simone Parent and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Growth hormone - releasing hormone in the immune system.Reviews in endocrine & metabolic disorders · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Mouse models of growth hormone deficiency.Reviews in endocrine & metabolic disorders · 2021
    Review
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Khalil FarhatGIGA-I3 Center of Immunoendocrinology, University of Liège, Liège, Belgium.
Gwennaëlle BodartGIGA-I3 Center of Immunoendocrinology, University of Liège, Liège, Belgium.
Chantal Charlet-RenardGIGA-I3 Center of Immunoendocrinology, University of Liège, Liège, Belgium.
Christophe J DesmetGIGA-I3 Cellular and Molecular Immunology, University of Liège, Liège, Belgium.
Michel MoutschenGIGA-I3 Infectious diseases, University of Liège, Liège, Belgium.
Yves BeguinGIGA-I3 Hematology, University of Liège, Liège, Belgium.
Frédéric BaronGIGA-I3 Hematology, University of Liège, Liège, Belgium.
Pierrette MelinDepartment of Clinical Microbiology, University Hospital of Liège, University of Liège, Liège, Belgium.
Pascale QuatresoozDepartment of Human Histology, University of Liège, Liège, Belgium.
Anne-Simone ParentDivision of Pediatric Endocrinology, University Hospital of Liège, Liège, Belgium.
Daniel DesmechtDepartment of Veterinary Pathology, University of Liège, Liège, Belgium.
Jean-Claude SirardCNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204-Center for Infection and Immunity of Lille, University of Lille, Lille, France.
Roberto SalvatoriJohns Hopkins University School of Medicine, Baltimore, MD, United States.
Henri MartensGIGA-I3 Center of Immunoendocrinology, University of Liège, Liège, Belgium.
Vincent G GeenenGIGA-I3 Center of Immunoendocrinology, University of Liège, Liège, Belgium.
University of Liège · BEInserm · FRJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise impact of the somatotrope axis upon the immune system is still highly debated. We have previously shown that mice with generalized ablation of growth hormone (GH) releasing hormone (GHRH) gene (

Indexed as

AnimalsB-LymphocytesGrowth HormoneGrowth Hormone-Releasing HormoneImmunoglobulin MInsulin-Like Growth Factor ILungMiceMice, KnockoutPneumococcal VaccinesSignal TransductionStreptococcus pneumoniaeGrowth HormoneGrowth Hormone-Releasing HormoneImmunoglobulin Minsulin-like growth factor-1, mouseInsulin-Like Growth Factor IPneumococcal VaccinesGHGHRHsomatotrope axisspleenS. pneumoniathymo-independent antigen

Identifiers

PMID30333823
PMCPMC6176084
OpenAlexW2890671986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.