Evidence map›Paper›PMID 30333798›Full record

ArticleFrontiers in microbiology2018

Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus.

Tianlong Liu, Peng Xiao, Ruiwen Li, Ruiping She, Jijing Tian, Jingyuan Wang, Jingjing Mao, Jun Yin, Ruihan Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Tianlong LiuLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Peng XiaoSanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
Ruiwen LiCollege of Traditional Chinese Veterinary Medicine, Hebei Agricultural University, Dingzhou, China.
Ruiping SheLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jijing TianLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jingyuan WangLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jingjing MaoLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jun YinLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Ruihan ShiLaboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
China Agricultural University · CNHebei Agricultural University · CNUniversity of South Dakota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, mechanism study of hepatitis E virus (HEV) infection has attracted an increasing attention because of the growing rate of the acute hepatitis caused by the virus over the world. As an important initiate in the inflammation, mast cells (MCs) play a critical role in maintaining a healthy physiology. However, the function of the MCs in the acute hepatitis caused by HEV is still unclear. In the present study, mongolian gerbils infected by HEV were used as an animal model to evaluate the role of MCs in the HEV infection. The positive ELISA and RT-PCR results showed the gerbils was successfully infected with HEV. The number of mast cell in the liver and the small intestine in the infected animals were growing higher significantly than the control group. In addition, higher expression of the tryptase and 5-HT in the liver and the intestine detected by immunohistochemical method and western blot also indicate the activation of MCs in the infection. These results suggest that MCs play an important role in the hepatitis E.

Indexed as

activationexperimental infectionhepatitis E virusmast cellmongolian gerbils

Identifiers

PMID30333798
PMCPMC6175998
OpenAlexW2895760083

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.