Evidence map›Paper›PMID 30333556›Full record

ArticleActa pharmacologica Sinica2019

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model.

Li-Lan Sun, Tao-Yi Yang, Ning-Ning Wei, Wei Lu, Wen-Xuan Jiao, Qi-Qi Zhou, Yong-Zhen Miao, Qin Gao, Xin-Tong Wang, Qi Sun and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Therapeutic Targeting ofPharmacological reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Li-Lan SunDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Tao-Yi YangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Ning-Ning WeiDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Wei LuDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Wen-Xuan JiaoState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Qi-Qi ZhouDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Yong-Zhen MiaoDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Qin GaoDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China.
Xin-Tong WangState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Qi SunState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. sunqi@bjmu.edu.cn.
KeWei WangDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266021, China. wangkw@qdu.edu.cn.
Qingdao University · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The α7 nicotinic acetylcholine receptor (α7 nAChR) is a ligand-gated Ca

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsDizocilpine MaleateHippocampusHumansInterneuronsLocomotionMaleMaze LearningMemory DisordersMice, Inbred C57BLNootropic AgentsPrepulse InhibitionRats, Sprague-DawleySchizophreniaSensory Gatingalpha7 Nicotinic Acetylcholine ReceptorDizocilpine MaleateNootropic AgentsThiazolescognitive deficitselectrophysiologyJWX-A0108positive allosteric modulatorprepulse inhibition of acoustic startlespatial working memorythiazolyl heterocyclic derivativeα7 nAChR

Identifiers

PMID30333556
PMCPMC6786413
OpenAlexW2897863783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.