Evidence map›Paper›PMID 30333551›Full record

ArticleThe American journal of gastroenterology2018

Web-Based Model for Predicting Time to Surgery in Young Patients with Familial Adenomatous Polyposis: An Internally Validated Study.

Shashank Sarvepalli, Carol A Burke, Marc Monachese, Rocio Lopez, Brandie H Leach, Lisa Laguardia, Margaret OʼMalley, Matthew F Kalady, James M Church

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
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  7. Update on Surgical Management of FAP.Clinics in colon and rectal surgery · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shashank SarvepalliDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Carol A BurkeDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Marc MonacheseDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Rocio LopezDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Brandie H LeachDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Lisa LaguardiaDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Margaret OʼMalleyDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Matthew F KaladyDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
James M ChurchDepartment of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH, USA. Department of Colorectal Surgery, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. Department of Biostatistics and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe timing of prophylactic colorectal surgery in patients with familial adenomatous polyposis (FAP) is based on the immediacy of the colorectal cancer risk. The ability to predict the need for surgery may help patients and their families plan in the context of life events and CRC risk. We created a model to predict the likelihood of surgery within 2 and 5 years of first colonoscopy at our institution.

methodsA single institution hereditary colorectal syndrome (Cologene™) database was interrogated for all patients with FAP having a deleterious APC mutation. Patients with first colonoscopy after age 30 and before year 2000 were excluded. Cox regression analysis was done to assess multiple factors associated with surgery, followed by stepwise Cox regression analysis to select an optimal model. Receiver operator curve (ROC) analysis was performed to assess the model.

resultsA total of 211 (53% female) patients were included. Forty-five percent underwent surgery after an average of 3.8 years of surveillance. The final model was created based on initial clinical characteristics (age, gender, BMI, family history of desmoids, genotype-phenotype correlation), initial colonoscopic characteristics (number of polyps, polyp size, presence of high-grade dysplasia); and on clinical events (chemoprevention and polypectomy). AUC was 0.87 and 0.84 to predict surgery within 2 and 5 years, respectively. The final model can be accessed at this website: http://app.calculoid.com/#/calculator/29638 .

conclusionThis web-based tool allows clinicians to stratify patients' likelihood of colorectal surgery within 2 and 5 years of their initial examination, based on clinical and endoscopic features, and using the philosophy of care guiding practice at this institution.

Indexed as

Models, BiologicalTime-to-TreatmentAdenomatous Polyposis ColiAdolescentAdultColonoscopyColorectal NeoplasmsFemaleFollow-Up StudiesHumansInternetMalePractice Guidelines as TopicProphylactic Surgical ProceduresRegistriesRisk Assessment

Identifiers

PMID30333551
PMCPMC6768586
OpenAlexW2897032665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.