ArticleNature communications2018
Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
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- Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans.Nature communications · 2025Article
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- The transcription factor unc-130/FOXD3/4 contributes to the biphasic calcium response required to optimize avoidance behavior.Scientific reports · 2022Article
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- Polymodal Functionality of C. elegans OLL Neurons in Mechanosensation and Thermosensation.Neuroscience bulletin · 2021Article
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Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors: reversal initiation and feeding suppression in response to different concentrations of quinine. Low concentrations of quinine are decoded in AIB by a low-threshold, fast-inactivation glutamate receptor GLR-1 and translated into reversal initiation. In contrast, high concentrations of quinine are decoded by a high-threshold, slow-inactivation glutamate receptor GLR-5 in AIB. After activation, GLR-5 evokes sustained Ca
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