ArticleBioscience reports2018
Protective effect of polydatin on radiation-induced injury of intestinal epithelial and endothelial cells.
Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Geranylgeranyl Transferase Inhibitors Mitigate Intestinal Radiation Toxicity.International journal of radiation oncology, biology, physics · 2026Article
- Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies.Toxics · 2023Review
- Polydatin radiosensitizes lung cancer while preventing radiation injuries by modulating tumor-infiltrating B cells.Journal of cancer research and clinical oncology · 2023Article
- Exosome-coated polydatin nanoparticles in the treatment of radiation-induced intestinal damage.Aging · 2023Article
- Nanodrugs with intrinsic radioprotective exertion: Turning the double-edged sword into a single-edged knife.Exploration (Beijing, China) · 2023Review
- [Polydatin improves intestinal barrier injury after traumatic brain injury in rats by reducing oxidative stress and inflammatory responseNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Development of a novel UPLC-MS/MS method for the simultaneously quantification of polydatin and resveratrol in plasma: Application to a pharmacokinetic study in rats.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021Article
- Exosomes are involved in total body irradiation-induced intestinal injury in mice.Acta pharmacologica Sinica · 2021Article
- Polydatin Attenuates 14.1 MeV Neutron-Induced Injuries via Regulating the Apoptosis and Antioxidative Pathways and Improving the Hematopoiesis of Mice.Oxidative medicine and cellular longevity · 2020Article
- Protective Effect of Polydatin on Jejunal Mucosal Integrity, Redox Status, Inflammatory Response, and Mitochondrial Function in Intrauterine Growth-Retarded Weanling Piglets.Oxidative medicine and cellular longevity · 2020Article
- Radiation Protection of Polydatin Against Radon Exposure Injury of Epithelial Cells and Mice.Dose-response : a publication of International Hormesis SocietyArticle
- Protective Effects of Polydatin on Reproductive Injury Induced by Ionizing Radiation.Dose-response : a publication of International Hormesis SocietyArticle
- Anti-Oxidative and Immuno-Protective Effect of Camel Milk on Radiation-Induced Intestinal Injury in C57BL/6 J Mice.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to examine the radioprotective effect of polydatin (PD) on crypt and endothelial cells of the small intestines of C57BL/6 mice that received abdominal irradiation (IR). Mice were treated with 6 MV X-ray (20 Gy) abdominal IR at a dose rate of 200 cGy/min. Thirty minutes before or after IR, mice were intraperitoneally injected with PD. The rate of survival of the mice at 30 days after IR was determined. The duodenum (upper small intestine), jejunum (middle small intestine), and ileum (lower small intestine) were collected and subjected to hematoxylin and eosin staining. Tissue sample sections were analyzed through light microscopy, and the lengths of at least 20 intestinal villi were measured in each group; the average number of crypts was obtained from 10 intestinal samples in each group. Microvessel density was assessed using CD31-positive (brown) vascular endothelial cells/cell clusters. FHs74Int cell proliferation was measured using the CCK-8 assay. PD administration (25 mg/kg) before IR was the most effective in prolonging the survival of C57BL/6 mice. PD reduced radiation-induced injury of intestinal villi, prevented loss of crypts, increased intestinal crypt growth, protected against IR-induced intestinal injury, and enhanced the proliferative potential and reduced the apoptosis of FHs74Int cells after IR. Moreover, PD increased small intestinal MVD and reduced the apoptosis of intestinal microvascular endothelial cells in mice after IR. Therefore, PD was found to be able to protect the two types of cells from radiation damage and to thus alleviate radiation-induced injury of small intestine.
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Registered trials
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