ArticleJournal of the Royal Society, Interface2018
Micromechanics of elastic lamellae: unravelling the role of structural inhomogeneity in multi-scale arterial mechanics.
Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Simulating the Transmural Mechanical Response of Functionally Graded Arterial Grafts.ACS applied bio materials · 2025Article
- Revisiting the biophysical aspects of extracellular-matrix-mimicking hydrogels: what cells seeBiomaterials science · 2025Review
- Concentric ice-templating of ultracompressible tough hydrogels with bioinspired circumferentially aligned architecture.Science advances · 2025Article
- CardioGraph: a platform to study variations associated with familiar cardiopathies.BMC medical informatics and decision making · 2024Article
- Experimental Protocols to Test Aortic Soft Tissues: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension.Scientific reports · 2024Article
- Compromised homeostasis in aged carotid arteries revealed by microstructural studies of elastic lamellae.Journal of the mechanical behavior of biomedical materials · 2023Article
- Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- Hydrocolloids of Egg White and Gelatin as a Platform for Hydrogel-Based Tissue Engineering.Gels (Basel, Switzerland) · 2023Article
- Female C57BL/6N mice are a viable model of aortic aging in women.American journal of physiology. Heart and circulatory physiology · 2023Article
- A novel constitutive model considering the role of elastic lamellae' structural heterogeneity in homogenizing transmural stress distribution in arteries.Journal of the Royal Society, Interface · 2023Article
- Anti-Inflammatory and Anti-Thrombogenic Properties of Arterial Elastic Laminae.Bioengineering (Basel, Switzerland) · 2023Review
- Through the cleared aorta: three-dimensional characterization of mechanical behaviors of rat thoracic aorta under intraluminal pressurization using optical clearing method.Scientific reports · 2022Article
- Simulating progressive intramural damage leading to aortic dissection using DeepONet: an operator-regression neural network.Journal of the Royal Society, Interface · 2022Article
- Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy.Mechanisms of ageing and development · 2021Article
- Review
- Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan Aorta.Frontiers in cardiovascular medicine · 2021Article
- Effect of Glycation on Interlamellar Bonding of Arterial Elastin.Experimental mechanics · 2021Article
- Synchrotron-based visualization and segmentation of elastic lamellae in the mouse carotid artery during quasi-static pressure inflation.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Microstructural deformation of elastic lamellae plays important roles in maintaining arterial tissue homeostasis and regulating vascular smooth muscle cell fate. Our study unravels the underlying microstructural origin that enables elastic lamellar layers to evenly distribute the stresses through the arterial wall caused by intraluminal distending pressure, a fundamental requirement for tissue and cellular function. A new experimental approach was developed to quantify the spatial organization and unfolding of elastic lamellar layers under pressurization in mouse carotid arteries by coupling physiological extension-inflation and multiphoton imaging. Tissue-level circumferential stretch was obtained from analysis of the deformation of a thick-walled cylinder. Our results show that the unfolding and extension of lamellar layers contribute simultaneously to tissue-level deformation. The inner lamellar layers are wavier and unfold more than the outer layers. This waviness gradient compensates the larger tissue circumferential stretch experienced at the inner surface, thus equalizing lamellar layer extension through the arterial wall. Discoveries from this study reveal the importance of structural inhomogeneity in maintaining tissue homeostasis through the arterial wall, and may have profound implications on vascular remodelling in aging and diseases, as well as in tissue engineering of functional blood vessels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.