Trial reportScience translational medicine2018
A dysbiotic microbiome triggers T
Abstract readClinical Trial
In one paragraph
Trial report in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 240 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
240citing papers in PubMed, 4 pooled it
28.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
240 citing papers in PubMed, 4 syntheses or guidelines pooled it, 350 citations in OpenAlex.
- The Microbiome in Hidradenitis Suppurativa Tunnels: A Systematic Review.International journal of dermatology · 2025Pooled it
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture.BMC oral health · 2025Pooled it
- Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Drug Target Candidates.International journal of molecular sciences · 2022Pooled it
- A systematic review and critical appraisal of metagenomic and culture studies in hidradenitis suppurativa.Experimental dermatology · 2021Pooled it
- Phase IIa clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation.The Journal of clinical investigation · 2021Trial
- Inflammatory Status and Glycemic Control Level of Patients with Type 2 Diabetes and Periodontitis: A Randomized Clinical Trial.International journal of environmental research and public health · 2021Trial
- The dynamic landscape of T helper cell plasticity and Th17-Treg instability in periodontitis.Experimental & molecular medicine · 2026Review
- Polymicrobial-driven NLRP6 inflammasome regulates IL-1β production and alveolar bone loss in a murine model of periodontitis.PLoS pathogens · 2026Article
- Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- TAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Longitudinal Salivary Immunophenotyping Reveals Distinct Cellular Signatures of Periodontal Disease Activity and Resolution.bioRxiv : the preprint server for biology · 2026Article
- CD69 Regulates Gingival Inflammation and Microbiome in Periodontitis.Journal of dental research · 2026Article
- Th17/IL-17A Drives Alveolar Bone Loss via the JAK/STAT3-RANKL Axis in the Periodontal Ligament.Oral diseases · 2026Article
- Nanoengineered bile acid-mediated orchestration of versatile immuno-microbial cues for treating periodontitis.Journal of nanobiotechnology · 2026Article
- Tissue-specific adaptation of human T cells is preserved during tissue inflammation.bioRxiv : the preprint server for biology · 2026Article
- Porphyromonas gingivalis induces intestinal inflammation through gingipain-dependent gut microbiome dysbiosis.Microbiome · 2026Article
- Mucosal Inflammation Shapes Human Neutrophil States in Tissue and Circulation.bioRxiv : the preprint server for biology · 2026Article
- Distinct spatial organization governs oral mucosal immunity.Nature immunology · 2026Article
- Core-shell microneedles with MMP/pH-triggered release for periodontitis bone repair.Journal of nanobiotechnology · 2026Article
180 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 4 countries.
Nicolas DutzanOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-8343-0214
Tetsuhiro KajikawaDepartment of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8416-9126
Loreto AbuslemeOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-7210-1236
Teresa Greenwell-WildOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.
Carlos E ZuazoOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.
Tomoko IkeuchiOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-5210-3883
Laurie BrenchleyOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA.
Toshiharu AbeDepartment of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8810-4861
Charlotte HurabielleMucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, MD 20892, USA.
Daniel MartinGenomics and Computational Biology Core, NIDCD, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-8880-9087
Robert J MorellGenomics and Computational Biology Core, NIDCD, NIH, Bethesda, MD 20892, USA.
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD 20892, USA.
Vanja LazarevicExperimental Immunology Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
Giorgio TrinchieriCancer and Inflammation Program, CCR, NCI, NIH, Bethesda, MD 20892, USA.
Patricia I DiazSchool of Dental Medicine, UConn Health, Farmington, CT 06030, USA.ORCID 0000-0002-9501-1145
Steven M HollandLaboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-3207-5464
Yasmine BelkaidMucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, MD 20892, USA.ORCID 0000-0001-9962-3571
George HajishengallisDepartment of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7392-8852
Niki M MoutsopoulosOral Immunity and Inflammation Unit, NIDCR, NIH, Bethesda, MD 20892, USA. nmoutsop@mail.nih.gov.ORCID 0000-0002-7365-6735
National Institute of Dental and Craniofacial Research · USNational Institutes of Health · USUniversity of Pennsylvania · USCenter for Cancer Research · USUniversidad de Santiago de Chile · CLInserm · FRJiangsu Institute of Parasitic Diseases · CNUConn Health · US
Funding
Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6MRole of the microbiota in immunityZIAAI001115 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BELKAID, YASMINE · 2009 to 2025
$22.4MTransgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2MRole of mouse microbiome in cancer and inflammationZIABC011153 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$22.0MGenomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8MNIAID Microbiome ProgramZICAI001233 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MOUTSOPOULOS, NIKI · 2018 to 2025
$18.9MMechanisms of Chronic Inflammation in PeriodontitisZIADE000736 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MOUTSOPOULOS, NIKI · 2010 to 2025
$14.1MOral Microbial and Immunological Characterization of Patients with Immune DysfunZIADE000732 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MOUTSOPOULOS, NIKI · 2010 to 2024
$13.2MPrimary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7MLocal endogenous regulators of functional immune plasticity in the periodontiumR37DE026152 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2016 to 2025
$3.5MNeutrophil homeostasis and periodontitis: Novel concepts and treatmentsR01DE024153 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI HAJISHENGALLIS, GEORGIOS · 2016 to 2020
$2.0MIntramural NIH HHS ZIA DE000736NIDCR NIH HHS R01 DE024153NIDCR NIH HHS R37 DE026152
Abstract
Periodontitis is one of the most common human inflammatory diseases, yet the mechanisms that drive immunopathology and could be therapeutically targeted are not well defined. Here, we demonstrate an expansion of resident memory T helper 17 (T
Indexed as
MicrobiotaAnimalsBacteriaBone ResorptionCell DifferentiationDysbiosisHumansInflammationInterleukin-23Interleukin-6MiceMouth MucosaNeutrophilsNuclear Receptor Subfamily 1, Group F, Member 3PeriodontitisTh17 CellsInterleukin-23Interleukin-6Nuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mouse
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What OpenQuestion holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.