ArticleDevelopment (Cambridge, England)2018
Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis.
Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Loss of Hippo Signaling Causes Coloboma via Steric Obstruction of Optic Fissure Fusion.Investigative ophthalmology & visual science · 2026Article
- Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development.Development (Cambridge, England) · 2026Article
- Targeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control.Translational vision science & technology · 2026Article
- Loss of Hippo signaling causes transdifferentiation of neural retina between the optic fissure edges causing coloboma.bioRxiv : the preprint server for biology · 2026Article
- Resolving forebrain developmental organisation by analysis of differential growth patterns.Nature communications · 2025Article
- Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- DNA methyltransferase 1 regulates epithelial cell functions in corneal and eyelid development.Molecular vision · 2025Article
- A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma.Cell reports · 2024Article
- Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation.bioRxiv : the preprint server for biology · 2024Article
- Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Signaling - transcription interactions in mouse retinal ganglion cells early axon pathfinding -a literature review.Frontiers in ophthalmology · 2023Review
- Expanding the phenotype of males with OFD1 pathogenic variants-a case report and literature review.European journal of medical genetics · 2022Article
- Pax2a, but not pax2b, influences cell survival and periocular mesenchyme localization to facilitate zebrafish optic fissure closure.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish.G3 (Bethesda, Md.) · 2022Article
- Eyes on CHARGE syndrome: Roles of CHD7 in ocular development.Frontiers in cell and developmental biology · 2022Review
- Loss of zebrafish dzip1 results in inappropriate recruitment of periocular mesenchyme to the optic fissure and ocular coloboma.PloS one · 2022Article
- Eye morphogenesis in the blind Mexican cavefish.Biology open · 2021Article
- Build me up optic cup: Intrinsic and extrinsic mechanisms of vertebrate eye morphogenesis.Developmental biology · 2021Review
- 4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis.Journal of visualized experiments : JoVE · 2021Article
- Chimeric Claudins: A New Tool to Study Tight Junction Structure and Function.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Establishment of precise three-dimensional tissue structure is vital for organ function. In the visual system, optic fissure and stalk morphogenesis is a crucial yet poorly understood process, disruptions of which can lead to coloboma, a birth defect causing visual impairment. Here, we use four-dimensional imaging, cell tracking, and molecular genetics in zebrafish to define the cell movements underlying normal optic fissure and stalk formation. We determine how these events are disrupted in a coloboma model in which the Hedgehog (Hh) receptor
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.