Evidence map›Paper›PMID 30333195›Full record

ReviewRNA (New York, N.Y.)2019

Post-transcriptional control of miRNA biogenesis.

Gracjan Michlewski, Javier F Cáceres

Open access · bronzeAbstract readReview
In one paragraph

Review in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 333 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
333citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

333 citing papers in PubMed, 3 syntheses or guidelines pooled it, 577 citations in OpenAlex.

  1. Pooled it
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  12. Integration of Omics Data to Identify Cancer-Related MicroRNA.Methods in molecular biology (Clifton, N.J.) · 2026
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273 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Gracjan MichlewskiDivision of Infection and Pathway Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.ORCID 0000-0002-7409-9619
Javier F CáceresMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.ORCID 0000-0001-8025-6169
Western General Hospital · GBZhejiang University-University of Edinburgh Institute · CN

Funding

Medical Research Council G1000564Medical Research Council MC_PC_U127584479Medical Research Council MC_UU_00007/7Wellcome Trust
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear and cytoplasmic processing events, carried out by the endoribonucleases DROSHA and DICER, respectively, to produce mature miRNAs that are loaded onto the RISC (RNA-induced silencing complex) to exert their biological function. Regulation of mature miRNA levels is critical in development, differentiation, and disease, as demonstrated by multiple levels of control during their biogenesis cascade. Here, we will focus on post-transcriptional mechanisms and will discuss the impact of

Indexed as

AnimalsCell NucleusCytoplasmGenetic VariationHumansMicroRNAsRibonuclease IIIRNA-Binding ProteinsRNA-Induced Silencing ComplexRNA PrecursorsRNA Processing, Post-TranscriptionalMicroRNAsRibonuclease IIIRNA-Binding ProteinsRNA-Induced Silencing ComplexRNA PrecursorsDGCR8DICERDROSHAMicroprocessormicroRNAs (miRNAs)RNA-binding proteins (RBPs)terminal loop

Identifiers

PMID30333195
PMCPMC6298569
OpenAlexW2896019639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.