Evidence map›Paper›PMID 30333182›Full record

ArticlemSphere2018

Phenotypic Variation in the Group A

Poulomee Sarkar, Jessica L Danger, Ira Jain, Laura A Meadows, Christopher Beam, Josette Medicielo, Cameron Burgess, James M Musser, Paul Sumby

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Poulomee SarkarDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Jessica L DangerDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Ira JainDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Laura A MeadowsDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Christopher BeamDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Josette MedicieloDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Cameron BurgessDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
James M MusserCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.
Paul SumbyDepartment of Microbiology & Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA psumby@med.unr.edu.ORCID 0000-0002-0093-4159
University of Nevada, Reno · USHouston Methodist · US

Funding

Modulating the pathogenic potential of the group A StreptococcusR21AI139400 · NIAID · UNIVERSITY OF NEVADA RENO · PI SUMBY, PAUL · 2018 to 2019
$393k
NIAID NIH HHS R21 AI139400
6 · The paper itself

Abstract

Populations of a bacterial pathogen, whether recovered from a single patient or from a worldwide study, are often a heterogeneous mix of genetically and phenotypically divergent strains. Such heterogeneity is of value in changing environments and arises via mechanisms such as gene gain or gene mutation. Here, we identify an isolate of serotype M12 group A

Indexed as

MutationSerogroupBacterial CapsulesBacterial ProteinsHistidine KinaseHumansIntracellular Signaling Peptides and ProteinsPeptide HydrolasesRepressor ProteinsRNA, MessengerStreptococcal InfectionsStreptococcus pyogenesTrans-ActivatorsVirulenceBacterial ProteinsCovS protein, Streptococcus pyogenesCsrR protein, Streptococcus pyogenesHistidine KinaseIntracellular Signaling Peptides and ProteinsPeptide HydrolasesRepressor ProteinsRNA, MessengerRocA protein, Streptococcus pyogenesSpyCEP protein, Streptococcus pyogenesTrans-Activatorsgene mutationgene regulationphenotypic variationStreptococcus pyogenes

Identifiers

PMID30333182
PMCPMC6193603
OpenAlexW2897562253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.