Evidence map›Paper›PMID 30333175›Full record

ArticleJournal of virology2019

Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication.

Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Yu Zhang, Takayuki Chikata, Mohamed Ali Borghan, Hiroyuki Gatanaga, Shinichi Oka, Keiko Sakai, Masafumi Takiguchi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. HIV-1-specific CD8PNAS nexus · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Control of HIV-1 Replication by CD8Journal of virology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Specificity of CD8Vaccines · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hayato Murakoshi *Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Nozomi Kuse *Center for AIDS Research, Kumamoto University, Kumamoto, Japan.
Tomohiro AkahoshiCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Yu ZhangCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Takayuki ChikataCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Mohamed Ali BorghanDepartment of Physiology and Biophysics, College of Medicine and Health Sciences, National University of Science and Technology, Sohar, Sultanate of Oman.
Hiroyuki GatanagaCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Shinichi OkaCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Keiko SakaiCenter for AIDS Research, Kumamoto University, Kumamoto, Japan.
Masafumi TakiguchiCenter for AIDS Research, Kumamoto University, Kumamoto, Japan masafumi@kumamoto-u.ac.jp.
Kumamoto University · JPNational Center for Global Health and Medicine · JPSohar University · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1-specific cytotoxic T-lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and recognize most circulating HIV-1 strains are candidates for effector T cells for cure treatment and prophylactic AIDS vaccine. Previous studies demonstrated that the existence of CTLs specific for 11 epitopes was significantly associated with good clinical outcomes in Japan, although CTLs specific for one of these epitopes select for escape mutations. However, it remains unknown whether the CTLs specific for the remaining 10 epitopes suppress HIV-1 replication

Indexed as

AIDS VaccinesCell LineEpitopes, T-LymphocyteHIV-1HIV InfectionsHLA-A AntigensHumansJapanMutationT-Lymphocytes, CytotoxicVirus ReplicationAIDS VaccinesEpitopes, T-LymphocyteHLA-A AntigensCTLcureepitopeHIV-1HLAvaccines

Identifiers

PMID30333175
PMCPMC6288335
OpenAlexW2896090400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.