Evidence map›Paper›PMID 30333171›Full record

ArticleJournal of virology2019

αvβ3 Integrin Is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26.

Davor Nestić, Taco G Uil, Jiangtao Ma, Soumitra Roy, Jort Vellinga, Andrew H Baker, Jerome Custers, Dragomira Majhen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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  8. Bioorthogonal PROTAC Prodrugs Enabled by On-Target Activation.Journal of the American Chemical Society · 2023
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  13. Journal of virology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Davor NestićLaboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia.
Taco G UilViral Vaccine Discovery and Early Development, Janssen Vaccines and Prevention BV, Leiden, The Netherlands.
Jiangtao MaGlasgow Cardiovascular Research Centre College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Soumitra RoyViral Vaccine Discovery and Early Development, Janssen Vaccines and Prevention BV, Leiden, The Netherlands.
Jort VellingaViral Vaccine Discovery and Early Development, Janssen Vaccines and Prevention BV, Leiden, The Netherlands.
Andrew H BakerCentre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Jerome CustersViral Vaccine Discovery and Early Development, Janssen Vaccines and Prevention BV, Leiden, The Netherlands JCuster1@its.jnj.com dmajhen@irb.hr.
Dragomira MajhenLaboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia JCuster1@its.jnj.com dmajhen@irb.hr.
Human Vaccines Project Europe · NLRudjer Boskovic Institute · HRJanssen (Netherlands) · NLUniversity of Edinburgh · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human adenoviruses (HAdVs) are being explored as vectors for gene transfer and vaccination. Human adenovirus type 26 (HAdV26), which belongs to the largest subgroup of adenoviruses, species D, has a short fiber and a so-far-unknown natural tropism. Due to its low seroprevalence, HAdV26 has been considered a promising vector for the development of vaccines. Despite the fact that the

Indexed as

A549 CellsAdenoviruses, HumanAdenovirus Infections, HumanCell LineCoxsackie and Adenovirus Receptor-Like Membrane ProteinEpithelial CellsHumansIntegrin alphaVbeta3Membrane Cofactor ProteinVirus InternalizationCoxsackie and Adenovirus Receptor-Like Membrane ProteinIntegrin alphaVbeta3Membrane Cofactor Proteinadenovirusesepithelial cellshuman adenovirus type 26receptorαvβ3 integrin

Identifiers

PMID30333171
PMCPMC6288336
OpenAlexW2897732259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.