Evidence map›Paper›PMID 30333162›Full record

ArticleNeurology2018

Neural dynamics of selective attention deficits in HIV-associated neurocognitive disorder.

Brandon J Lew, Timothy J McDermott, Alex I Wiesman, Jennifer O'Neill, Mackenzie S Mills, Kevin R Robertson, Howard S Fox, Susan Swindells, Tony W Wilson

Open access · bronzeAbstract read
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 75 citations in OpenAlex.

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  11. Oscillatory Dynamics Serving Verbal Working Memory Differ in People with HIV and Are Linked To Disease Duration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
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  12. Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Brandon J LewFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Timothy J McDermottFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Alex I WiesmanFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Jennifer O'NeillFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Mackenzie S MillsFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Kevin R RobertsonFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Howard S FoxFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Susan SwindellsFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill.
Tony W WilsonFrom the Departments of Neurological Sciences (B.J.L., T.J.M., A.I.W., M.S.M., T.W.W.), Internal Medicine (J.O., S.S.), and Pharmacology and Experimental Neuroscience (H.S.F.), University of Nebraska Medical Center, Omaha; and Department of Neurology (K.R.R.), University of North Carolina School of Medicine, Chapel Hill. twwilson@unmc.edu.
University of North Carolina at Chapel Hill · US

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2000 to 2021
$37.7M
THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECTR01MH116782 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2018 to 2022
$3.4M
Neurophysiological markers of HAND and the impact of aging: Evidence from MEGR01MH103220 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2014 to 2018
$2.5M
Neuroimmunology of Disease Training ProgramT32NS105594 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Aditya N Bade, Howard E Gendelman · 2018 to 2026
$1.4M
Oscillatory markers of cognitive deficits in patients with Alzheimer's diseaseF31AG055332 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WIESMAN, ALEX I · 2017 to 2019
$119k
NIA NIH HHS F31 AG055332NIMH NIH HHS P30 MH062261NIMH NIH HHS R01 MH103220NIMH NIH HHS R01 MH116782NINDS NIH HHS T32 NS105594
6 · The paper itself

Abstract

objectiveTo identify the neural markers of attention dysfunction in patients with HIV-associated neurocognitive disorder (HAND).

methodsSixty participants, including 40 HIV-infected adults (half with HAND) and 20 demographically matched controls performed a visual selective attention task while undergoing high-density magnetoencephalography. Neuronal activity related to selective attention processing was quantified and compared across the 3 groups, and correlated with neuropsychological measures of attention and executive function. Spontaneous neural activity was also extracted from these attention-related cortical areas and examined with respect to HAND status.

resultsHIV-infected participants with and without HAND exhibited behavioral selective attention deficits on the magnetoencephalography task, as indicated by an increased flanker effect. Neuronal measures of flanker interference activity in the alpha and theta range revealed differential dynamics in attention-related brain areas across the 3 groups, especially in those with HAND. In addition, theta range flanker interference activity in the left inferior frontal and dorsolateral prefrontal cortex was associated with executive function and attention composite scores, respectively. Progressively stronger spontaneous alpha and theta activity was also found in unimpaired HIV-infected and HAND participants relative to controls across brain regions implicated in different components of attention processing.

conclusionsBehavioral and neuronal metrics of selective attention performance distinguish participants with HAND from controls and unimpaired HIV-infected participants. These metrics, along with measures of local spontaneous neural activity, may hold promise as early markers of cognitive decline in participants with HIV infection and be useful prognostic indicators for HAND.

Indexed as

AdultAIDS Dementia ComplexAttentionBrainFemaleHumansMagnetoencephalographyMaleMiddle Aged

Identifiers

PMID30333162
PMCPMC6260195
OpenAlexW2897612411

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.