ArticleJournal of lipid research2018
Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix model.
Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Multiscale simulation of stratum corneum lipid mixtures: effects of ceramide headgroups on structural organization and hydrogen bonding networks.International journal of pharmaceutics · 2026Article
- Potential Enhancement of Topical Drug Delivery Using Grapefruit-derived Nanoparticles Modified Using TAT Peptide.Pharmaceutical research · 2026Article
- The phase behavior of skin-barrier lipids: A combined approach of experiments and simulations.Biophysical journal · 2024Article
- The Sphingosine and Phytosphingosine Ceramide Ratio in Lipid Models Forming the Short Periodicity Phase: An Experimental and Molecular Simulation Study.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Lipid Biomimetic Models as Simple Yet Complex Tools to Predict Skin Permeation and Drug-Membrane Biophysical Interactions.Pharmaceutics · 2024Review
- The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures.Biochimica et biophysica acta. Biomembranes · 2024Article
- Mechanisms of the Drug Penetration Enhancer Propylene Glycol Interacting with Skin Lipid Membranes.The journal of physical chemistry. B · 2024Article
- Chiral Supramolecular Hydrogel Enhanced Transdermal Delivery of Sodium Aescinate to Modulate M1 Macrophage Polarization Against Lymphedema.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The skin barrier: An extraordinary interface with an exceptional lipid organization.Progress in lipid research · 2023Review
- Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models.Journal of lipid research · 2023Article
- Article
- Using molecular simulation to understand the skin barrier.Progress in lipid research · 2022Review
- Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability.Journal of lipid research · 2022Article
- Transdermal Delivery Systems for Biomolecules.Journal of pharmaceutical innovation · 2022Review
- Increased Levels of Short-Chain Ceramides Modify the Lipid Organization and Reduce the Lipid Barrier of Skin Model Membranes.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- One Peptide for Them All: Gold Nanoparticles of Different Sizes Are Stabilized by a Common Peptide Amphiphile.ACS nano · 2020Article
- Coexistence of Lipid Phases Stabilizes Interstitial Water in the Outer Layer of Mammalian Skin.Biophysical journal · 2020Article
- Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lipid matrix of the stratum corneum, the outermost skin layer, consists primarily of ceramides, cholesterol, and FFAs. These lipids form a trilayer long-periodicity phase (LPP) that is unique to this barrier. Knowledge about the LPP is essential in understanding the barrier function. Previous studies of LPP lipid models have identified the position of the major lipid classes and suggested that a large fraction of FFAs and the ceramide acyl chain are present in the central region. However, the precise arrangement, such as lipid subclass mixing (isolated or mixed) and ceramide conformation (extended or hairpin), remains unknown. Here, we deuterated FFAs and the ceramide acyl chain to study CD
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