Evidence map›Paper›PMID 30333097›Full record

SynthesisJournal of medical Internet research2018

Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review.

Titus Josef Brinker, Achim Hekler, Jochen Sven Utikal, Niels Grabe, Dirk Schadendorf, Joachim Klode, Carola Berking, Theresa Steeb, Alexander H Enk, Christof von Kalle

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of medical Internet research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. A Systematic Review and Meta-analysis of Convolutional Neural Network in the Diagnosis of Colorectal Polyps and Cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
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  7. Digital Dermatology.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
    Review
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  11. Comparative diagnostic accuracy of ChatGPT models in salivary gland disease: a multimodal vignette-based evaluation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Titus Josef BrinkerNational Center for Tumor Diseases, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-3620-5919
Achim HeklerNational Center for Tumor Diseases, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-4974-2457
Jochen Sven UtikalSkin Cancer Unit, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0001-5316-0241
Niels GrabeBioquant, Hamamatsu Tissue Imaging and Analysis Center, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-1732-3706
Dirk SchadendorfDepartment of Dermatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-3524-7858
Joachim KlodeDepartment of Dermatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0001-9239-7014
Carola BerkingDepartment of Dermatology, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0003-0229-8931
Theresa SteebDepartment of Dermatology, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany.ORCID 0000-0002-9008-0088
Alexander H EnkDepartment of Dermatology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7358-185X
Christof von KalleNational Center for Tumor Diseases, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0001-9221-3297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundState-of-the-art classifiers based on convolutional neural networks (CNNs) were shown to classify images of skin cancer on par with dermatologists and could enable lifesaving and fast diagnoses, even outside the hospital via installation of apps on mobile devices. To our knowledge, at present there is no review of the current work in this research area.

objectiveThis study presents the first systematic review of the state-of-the-art research on classifying skin lesions with CNNs. We limit our review to skin lesion classifiers. In particular, methods that apply a CNN only for segmentation or for the classification of dermoscopic patterns are not considered here. Furthermore, this study discusses why the comparability of the presented procedures is very difficult and which challenges must be addressed in the future.

methodsWe searched the Google Scholar, PubMed, Medline, ScienceDirect, and Web of Science databases for systematic reviews and original research articles published in English. Only papers that reported sufficient scientific proceedings are included in this review.

resultsWe found 13 papers that classified skin lesions using CNNs. In principle, classification methods can be differentiated according to three principles. Approaches that use a CNN already trained by means of another large dataset and then optimize its parameters to the classification of skin lesions are the most common ones used and they display the best performance with the currently available limited datasets.

conclusionsCNNs display a high performance as state-of-the-art skin lesion classifiers. Unfortunately, it is difficult to compare different classification methods because some approaches use nonpublic datasets for training and/or testing, thereby making reproducibility difficult. Future publications should use publicly available benchmarks and fully disclose methods used for training to allow comparability.

Indexed as

Neural Networks, ComputerHumansReproducibility of ResultsSkin Neoplasmscarcinoma classificationconvolutional neural networksdeep learninglesion classificationmelanoma classificationskin cancer

Identifiers

PMID30333097
PMCPMC6231861

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.