ArticleArthritis research & therapy2018
Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.
Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- The effect of metformin in clinical studies on knee osteoarthritis: an updated systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis.Sports medicine - open · 2023Pooled it
- MRI T2 and T1ρ relaxation in patients at risk for knee osteoarthritis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2019Pooled it
- A New Stress Test for Knee Joint Cartilage.Scientific reports · 2019Trial
- Knee Osteoarthritis and Metabolic Disorders: Practical Aspects from Primary Healthcare.Journal of clinical medicine · 2026Article
- A novel integrative multi-scale framework of inflammation and mechanical loading in knee osteoarthritis.Biomechanics and modeling in mechanobiology · 2026Article
- Walking speed and sound limb loading are related to femoral cartilage thickness but not cartilage deformation in those with traumatic lower-limb amputation.Osteoarthritis and cartilage open · 2026Article
- Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics.Experimental physiology · 2026Review
- Associations Between Patient Characteristics and Cartilage T1ρ Relaxation Times Vary Over Time Following Patellar Dislocation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Circulating Metabolic Factors Mediating the Effect of Obesity-Related Indicators on Meniscal Injuries: A Mendelian Randomization Study.International journal of genomics · 2026Article
- The application of transfer learning to T1ρ MRI tibiofemoral cartilage segmentation.Journal of biomechanics · 2026Article
- The Relationship between Joint Loading and Physical Activity Level in Middle-Aged Adults with Obesity, and the Role of Body Composition.Medicine and science in sports and exercise · 2026Article
- Exercise-Induced Changes in Knee Cartilage In Vivo: Comparing MRI Sequences.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.Journal of biomechanics · 2025Article
- Resting Supine for 45 Minutes Yields Consistent Baseline Lumbar Intervertebral Disc Height in Asymptomatic Participants.Annals of biomedical engineering · 2025Article
- Aberrant Gait Biomechanics Linked to Cartilage Changes After ACL Reconstruction in Those With High Body Mass Index.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication.Annals of biomedical engineering · 2025Article
- MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.Scientific reports · 2025Article
- Patellofemoral Cartilage Degradation Based on T1ρ Relaxation Times Varies Inversely With BMI After Patellar Dislocation.Orthopaedic journal of sports medicine · 2025Article
- Microphysiological System-Generated Physiological Shear Forces Reduce TNF-α-Mediated Cartilage Damage in a 3D Model of Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundObesity is a primary risk factor for the development of knee osteoarthritis (OA). However, there remains a lack of in vivo data on the influence of obesity on knee cartilage mechanics and composition. The purpose of this study was to determine the relationship between obesity and tibiofemoral cartilage properties.
methodsMagnetic resonance images (3T) of cartilage geometry (double-echo steady-state) and T1rho relaxation of the knee were obtained in healthy subjects with a normal (n = 8) or high (n = 7) body mass index (BMI) before and immediately after treadmill walking. Subjects had no history of lower limb injury or surgery. Bone and cartilage surfaces were segmented and three-dimensional models were created to measure cartilage thickness and strain. T1rho relaxation times were measured before exercise in both the tibial and femoral cartilage in order to characterize biochemical composition. Body fat composition was also measured.
resultsSubjects with a high BMI exhibited significantly increased tibiofemoral cartilage strain and T1rho relaxation times (P <0.05). Tibial pre-exercise cartilage thickness was also affected by BMI (P <0.05). Correlational analyses revealed that pre-exercise tibial cartilage thickness decreased with increasing BMI (R
conclusionsStrains and T1rho relaxation times in the tibiofemoral cartilage were increased in high BMI subjects compared with normal BMI subjects. Additionally, pre-exercise tibial cartilage thickness decreased with obesity. Reduced proteoglycan content may be indicative of pre-symptomatic osteoarthritic degeneration, resulting in reduced cartilage thickness and increased deformation of cartilage in response to loading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.