ArticleBMC infectious diseases2018
Genetic characterization of norovirus GII.4 variants circulating in Canada using a metagenomic technique.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase.Scientific reports · 2026Article
- Molecular epidemiology of viral enteric in children in Hangzhou.BMC infectious diseases · 2025Article
- Genomic characterization of noroviruses from an outbreak associated with oysters.Microbiology spectrum · 2025Article
- Whole-Genome Sequencing-Based Confirmatory Methods on RT-qPCR Results for the Detection of Foodborne Viruses in Frozen Berries.Food and environmental virology · 2024Article
- Molecular Evolution of GII.P31/GII.4_Sydney_2012 Norovirus over a Decade in a Clinic in Japan.International journal of molecular sciences · 2024Article
- Metagenomic Surveillance of Viral Gastroenteritis in a Public Health Setting.Microbiology spectrum · 2023Article
- Antiviral Activities of Asarones and Rhizomes ofViruses · 2022Article
- Genomic stratification and differential natural selection signatures among human norovirus genogroup II isolates.Archives of virology · 2022Article
- Acute Infectious Gastroenteritis: The Causative Agents, Omics-Based Detection of Antigens and Novel Biomarkers.Children (Basel, Switzerland) · 2021Review
- Survival and Inactivation by Advanced Oxidative Process of Foodborne Viruses in Model Low-Moisture Foods.Food and environmental virology · 2021Article
- Pairing of Parental Noroviruses with Unequal Competitiveness Provides a Clear Advantage for Emergence of Progeny Recombinants.Applied and environmental microbiology · 2021Article
- Genomic analysis of human noroviruses using combined Illumina-Nanopore data.Virus evolution · 2021Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman norovirus is the leading cause of viral gastroenteritis globally, and the GII.4 has been the most predominant genotype for decades. This genotype has numerous variants that have caused repeated epidemics worldwide. However, the molecular evolutionary signatures among the GII.4 variants have not been elucidated throughout the viral genome.
methodA metagenomic, next-generation sequencing method, based on Illumina RNA-Seq, was applied to determine norovirus sequences from clinical samples.
resultsHerein, the obtained deep-sequencing data was employed to analyze full-genomic sequences from GII.4 variants prevailing in Canada from 2012 to 2016. Phylogenetic analysis demonstrated that the majority of these sequences belong to New Orleans 2009 and Sydney 2012 strains, and a recombinant sequence was also identified. Genome-wide similarity analyses implied that while the capsid gene is highly diverse among the isolates, the viral protease and polymerase genes remain relatively conserved. Numerous amino acid substitutions were observed at each putative antigenic epitope of the VP1 protein, whereas few amino acid changes were identified in the polymerase protein. Co-infection with other enteric RNA viruses was investigated and the astrovirus genome was identified in one of the samples.
conclusionsOverall this study demonstrated the application of whole genome sequencing as an important tool in molecular characterization of noroviruses.
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