ArticleMarine drugs2018
For a Correct Application of the CD Exciton Chirality Method: The Case of Laucysteinamide A.
Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Structure-Response Relationships in Rigid CChemphyschem : a European journal of chemical physics and physical chemistry · 2026Review
- 5-Demethoxy-10'-ethoxyexotimarin F, a New Coumarin with MAO-B Inhibitory Potential fromMolecules (Basel, Switzerland) · 2022Article
- ECD exciton chirality method today: a modern tool for determining absolute configurations.Chirality · 2022Review
- Induced axial chirality by a tight belt: naphthalene chromophores fixed in a 2,5-substituted cofacialJournal of materials chemistry. C · 2021Article
- Accurate Modeling of Excitonic Coupling in Cyanine Dye Cy3.The journal of physical chemistry. A · 2021Article
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Authors and funding
1 author.
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No grant is acknowledged in the PubMed record.
Abstract
The circular dichroism (CD) exciton chirality method (ECM) is a very popular approach for assigning the absolute configuration (AC) of natural products, thanks to its immediacy and ease of application. The sign of an exciton couplet (two electronic CD bands with opposite sign and similar intensity) can be directly correlated with the molecular stereochemistry, including the AC. However, a correct application of the ECM necessitates several prerequisites: knowledge of the molecular conformation; knowledge of transition moment direction; and preeminence of the exciton coupling mechanism with respect to other sources of CD signals. In recent years, by using quantum-chemical CD calculations, we have demonstrated that some previous applications of ECM were wrong or based on incorrect assumptions. In a recent publication of this journal (
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