ArticleInternational journal of molecular sciences2018
Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Osteo-immunological impact of radon spa treatment: due to radon or spa alone? Results from the prospective, thermal bath placebo-controlled RAD-ON02 trial.Frontiers in immunology · 2023Trial
- Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients.Frontiers in immunology · 2021Trial
- Computer Tomography-Based Target Volume Delineation and Clinical Outcomes of Low-Dose Radiation Therapy for Knee Osteoarthritis.Advances in radiation oncology · 2026Article
- Low-Dose Radiation Therapy for Osteoarthritis: Analysis of Preliminary Outcomes at Scripps Clinic.Advances in radiation oncology · 2026Article
- From essential basic understanding to clinical application - biological, physical and pathophysiological principles of (low-dose) radiotherapy in benign diseases.Frontiers in immunology · 2025Review
- Low-dose Radiation Therapy (LDRT) in Managing Osteoarthritis: A Comprehensive Review.Current therapeutic research, clinical and experimental · 2025Review
- Preventive and therapeutic effects of low-dose whole-body irradiation on collagen-induced rheumatoid arthritis in mice.Journal of radiation research · 2024Article
- Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects-challenges for future studies.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Review
- Neglected immunoregulation: M2 polarization of macrophages triggered by low-dose irradiation plays an important role in bone regeneration.Journal of cellular and molecular medicine · 2023Article
- Article
- Modulation of Differentiation and Bone Resorbing Activity of Human (Pre-) Osteoclasts After X-Ray Exposure.Frontiers in immunology · 2022Article
- Radiotherapy CT-based contouring atlas for non-malignant skeletal and soft tissue disorders: a practical proposal from Spanish experience.The British journal of radiology · 2021Review
- Article
- Low dose ionizing radiation effects on the immune system.Environment international · 2021Review
- The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts.International journal of molecular sciences · 2020Review
- Organ-Specific Effects of Low Dose Radiation Exposure: A Comprehensive Review.Frontiers in genetics · 2020Review
- Linac-based radiotherapy for epicondylitis humeri.EXCLI journal · 2020Article
- Low-Dose Irradiation Differentially Impacts Macrophage Phenotype in Dependence of Fibroblast-Like Synoviocytes and Radiation Dose.Journal of immunology research · 2019Article
- Positive impact of low-dose, high-energy radiation on bone in partial- and/or full-weightbearing mice.NPJ microgravity · 2019Article
- Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Low-dose radiotherapy (LD-RT) for benign inflammatory and/or bone destructive diseases has been used long. Therefore, mechanistic investigations on cells being present in joints are mostly made in an inflammatory setting. This raises the question whether similar effects of LD-RT are also seen in healthy tissue and thus might cause possible harmful effects. We performed examinations on the functionality and phenotype of key cells within the joint, namely on fibroblast-like synoviocytes (FLS), osteoclasts and osteoblasts, as well as on immune cells. Low doses of ionizing radiation showed only a minor impact on cytokine release by healthy FLS as well as on molecules involved in cartilage and bone destruction and had no significant impact on cell death and migration properties. The bone resorbing abilities of healthy osteoclasts was slightly reduced following LD-RT and a positive impact on bone formation of healthy osteoblasts was observed after in particular exposure to 0.5 Gray (Gy). Cell death rates of bone-marrow cells were only marginally increased and immune cell composition of the bone marrow showed a slight shift from CD8⁺ to CD4⁺ T cell subsets. Taken together, our results indicate that LD-RT with particularly a single dose of 0.5 Gy has no harmful effects on cells of healthy joints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.