ArticleInternational journal of molecular sciences2018
Zinc Chloride Exposure Inhibits Brain Acetylcholine Levels, Produces Neurotoxic Signatures, and Diminishes Memory and Motor Activities in Adult Zebrafish.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
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- The Effect of the Antidepressant Citalopram on the Bioconcentration and Biomarker Response ofToxics · 2025Article
- Chronic dimethomorph exposure induced behaviors abnormalities and cognitive performance alterations in adult zebrafish (Toxicology reports · 2025Article
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- Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds.International journal of molecular sciences · 2025Review
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- Single and Combined Effects of Chlorpyrifos and Glyphosate on the Brain of Common Carp: Based on Biochemical and Molecular Perspective.International journal of molecular sciences · 2023Article
- Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos.International journal of molecular sciences · 2023Article
- Oxidative Stress and Neurotoxicity of Cadmium and Zinc on Artemia franciscana.Biological trace element research · 2023Article
- Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity.The Science of the total environment · 2023Article
- Temperature- and chemical-induced neurotoxicity in zebrafish.Frontiers in physiology · 2023Review
- Zebrafish: A Pharmacological Model for Learning and Memory Research.Molecules (Basel, Switzerland) · 2022Review
- Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish.International journal of molecular sciences · 2021Article
- Impact of mycogenic zinc nanoparticles on performance, behavior, immune response, and microbial load inSaudi journal of biological sciences · 2021Article
- An Overview of Methods for Cardiac Rhythm Detection in Zebrafish.Biomedicines · 2020Review
- The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons.Antioxidants (Basel, Switzerland) · 2020Article
- Effect of salinity on zinc toxicity (ZnClEnvironmental science and pollution research international · 2020Article
- Surface Modification of Magnetic Nanoparticles by Carbon-Coating Can Increase Its Biosafety: Evidences from Biochemical and Neurobehavioral Tests in Zebrafish.Molecules (Basel, Switzerland) · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In this study, we evaluated the acute (24, 48, 72, and 96 h) and chronic (21 days) adverse effects induced by low doses (0.1, 0.5, 1, and 1.5 mg/L) of zinc chloride (ZnCl₂) exposure in adult zebrafish by using behavioral endpoints like three-dimensional (3D) locomotion, passive avoidance, aggression, circadian rhythm, and predator avoidance tests. Also, brain tissues were dissected and subjected to analysis of multiple parameters related to oxidative stress, antioxidant responses, superoxide dismutase (SOD), neurotoxicity, and neurotransmitters. The results showed that ZnCl₂-exposed fishes displayed decreased locomotor behavior and impaired short-term memory, which caused an Alzheimer's Disease (AD)-like syndrome. In addition, low concentrations of ZnCl₂ induced amyloid beta (amyloid β) and phosphorylated Tau (p-Tau) protein levels in brains. In addition, significant induction in oxidative stress indices (reactive oxygen species (ROS) and malondialdehyde (MDA)), reduction in antioxidant defense system (glutathione (GSH), GSH peroxidase (GSH-Px) and SOD) and changes in neurotransmitters were observed at low concentrations of ZnCl₂. Neurotoxic effects of ZnCl₂ were observed with significant inhibition of acetylcholine (ACh) activity when the exposure dose was higher than 1 ppm. Furthermore, we found that zinc, metallothionein (MT), and cortisol levels in brain were elevated compared to the control group. A significantly negative correlation was observed between memory and acetylcholinesterase (AChE) activity. In summary, these findings revealed that exposure to ZnCl₂ affected the behavior profile of zebrafish, and induced neurotoxicity which may be associated with damaged brain areas related to memory. Moreover, our ZnCl₂-induced zebrafish model may have potential for AD-associated research in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.