Evidence map›Paper›PMID 30332787›Full record

ArticleNutrients2018

Prebiotics for Lactose Intolerance: Variability in Galacto-Oligosaccharide Utilization by Intestinal

Jason W Arnold, Joshua B Simpson, Jeffery Roach, Jose M Bruno-Barcena, M Andrea Azcarate-Peril

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Effects ofNutrients · 2019
    Trial
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  10. Biosorption of Heavy Metals by Lactic Acid Bacteria for Detoxification.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
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  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jason W ArnoldCenter for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. jason_arnold@med.unc.edu.
Joshua B SimpsonCenter for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. joshsimp@live.unc.edu.
Jeffery RoachResearch Computing, University of North Carolina, Chapel Hill, NC 27599, USA. jeff_roach@unc.edu.
Jose M Bruno-BarcenaDepartment of Plant and Microbial Biology, North Carolina State University, Raleigh, NC 27607, USA. jbbarcen@ncsu.edu.
M Andrea Azcarate-PerilCenter for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, and UNC Microbiome Core, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. azcarate@med.unc.edu.ORCID 0000-0003-0325-1289
University of North Carolina at Chapel Hill · USNorth Carolina State University · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
National Institute of Diabetes and Digestive and Kidney Diseases P30DK34987
6 · The paper itself

Abstract

Lactose intolerance, characterized by a decrease in host lactase expression, affects approximately 75% of the world population. Galacto-oligosaccharides (GOS) are prebiotics that have been shown to alleviate symptoms of lactose intolerance and to modulate the intestinal microbiota, promoting the growth of beneficial microorganisms. We hypothesized that mechanisms of GOS utilization by intestinal bacteria are variable, impacting efficacy and response, with differences occurring at the strain level. This study aimed to determine the mechanisms by which human-derived

Indexed as

Gastrointestinal MicrobiomePrebioticsGlycoside HydrolasesHumansLacticaseibacillus rhamnosusLactose IntoleranceOligosaccharides6-phospho-beta-galactosidaseGlycoside HydrolasesOligosaccharidesPrebioticsgalacto-oligosaccharidesLactobacillusprebiotics for lactose intoleranceprobioticsβ-galactosidases

Identifiers

PMID30332787
PMCPMC6213946
OpenAlexW2897074072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.