ArticleInternational journal of environmental research and public health2018
Sex-Dependent Impact of Low-Level Lead Exposure during Prenatal Period on Child Psychomotor Functions.
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Neurodevelopmental Outcomes Associated with Early-Life Exposure to Heavy Metals: A Systematic Review.International journal of environmental research and public health · 2025Pooled it
- Blood lead levels ≤10 micrograms/deciliter and executive functioning across childhood development: A systematic review.Neurotoxicology and teratologyPooled it
- Article
- Lead exposure and risk of ADHD and conduct disorders in children: evidence from a retrospective cohort in Philadelphia, PA.Environmental health : a global access science source · 2026Article
- Current Understanding of Sex Differences in Metal-Induced Diseases.Current environmental health reports · 2025Review
- Article
- Article
- Lead Decreases Bone Morphogenetic Protein-7 (BMP-7) Expression and Increases Renal Cell Carcinoma Growth in a Sex-Divergent Manner.International journal of molecular sciences · 2024Article
- Sex-specific associations between co-exposure to multiple metals and externalizing symptoms in adolescence and young adulthood.Environmental research · 2024Article
- Gender-Specific Effects on the Cardiorespiratory System and Neurotoxicity of Intermittent and Permanent Low-Level Lead Exposures.Biomedicines · 2024Article
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review.Frontiers in public health · 2024Review
- Assessing lead exposure in U.S. pregnant women using biological and residential measurements.The Science of the total environment · 2023Article
- REPRO_PL-Polish Mother and Child Cohort-Exposure, Health Status, and Neurobehavioral Assessments in Adolescents-Design and Cohort Update.International journal of environmental research and public health · 2022Article
- Parent report of child behaviour: Findings from the Flint Registry cohort.Paediatric and perinatal epidemiology · 2022Article
- Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms.Environmental research · 2021Review
- Environmental Tobacco Smoke and Early Language Difficulties among U.S. Children.International journal of environmental research and public health · 2021Article
- Prenatal metal mixtures and sex-specific infant negative affectivity.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive.Environmental sciences Europe · 2021Review
- (Ascorb)ing Pb Neurotoxicity in the Developing Brain.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of exposure to lead on child neurodevelopment has been well established. However, sex differences in vulnerability are still not fully explained. We aimed at evaluating the effect of a low-level lead exposure, as measured between 20 to 24 weeks of pregnancy and in cord blood, on developmental scores up to 24 months of age in 402 children from the Polish Mother and Child Cohort (REPRO_PL). Additionally, sex-dependent susceptibility to lead at this very early stage of psychomotor development was assessed. The blood lead levels were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). In order to estimate the children's neurodevelopment, the Bayley Scales of Infant and Toddler Development was applied. The geometric mean (GM) for blood lead level during 20⁻24 weeks of pregnancy was 0.99 ± 0.15 µg/dL and, in the cord blood, it was 0.96 ± 0.16 µg/dL. There was no statistically significant impact of lead exposure during prenatal period on the girls' psychomotor abilities. Among the boys, we observed lower scores for cognitive functions, along with increasing cord blood lead levels (β = -2.07;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.