Evidence map›Paper›PMID 30332744›Full record

ReviewNutrients2018

Dietary Choline Intake: Current State of Knowledge Across the Life Cycle.

Alejandra M Wiedeman, Susan I Barr, Timothy J Green, Zhaoming Xu, Sheila M Innis, David D Kitts

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  3. The use of choline supplementation in premature newborns: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
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129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alejandra M WiedemanBC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada. awiedeman@bcchr.ca.ORCID 0000-0002-2149-2302
Susan I BarrFood, Nutrition, and Health Program, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada. susan.barr@ubc.ca.ORCID 0000-0001-8701-7152
Timothy J GreenBC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada. tim.green@sahmri.com.ORCID 0000-0002-0667-4300
Zhaoming XuFood, Nutrition, and Health Program, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada. zhaoming.xu@ubc.ca.
Sheila M InnisBC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.
David D KittsFood, Nutrition, and Health Program, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada. david.kitts@ubc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choline, an essential dietary nutrient for humans, is required for the synthesis of the neurotransmitter, acetylcholine, the methyl group donor, betaine, and phospholipids; and therefore, choline is involved in a broad range of critical physiological functions across all stages of the life cycle. The current dietary recommendations for choline have been established as Adequate Intakes (AIs) for total choline; however, dietary choline is present in multiple different forms that are both water-soluble (e.g., free choline, phosphocholine, and glycerophosphocholine) and lipid-soluble (e.g., phosphatidylcholine and sphingomyelin). Interestingly, the different dietary choline forms consumed during infancy differ from those in adulthood. This can be explained by the primary food source, where the majority of choline present in human milk is in the water-soluble form, versus lipid-soluble forms for foods consumed later on. This review summarizes the current knowledge on dietary recommendations and assessment methods, and dietary choline intake from food sources across the life cycle.

Indexed as

Nutritional RequirementsAcetylcholineAdultBetaineCholineDietEatingHuman DevelopmentHumansInfantMilk, HumanPhospholipidsAcetylcholineBetaineCholinePhospholipidsadequate intakebreast milkcholinedietary assessmentdietary choline formsdietary recommendationshuman milk

Identifiers

PMID30332744
PMCPMC6213596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.