ArticleCell reports2018
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 74 citations in OpenAlex.
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Authors and funding
21 authors at 5 institutions in 4 countries.
Ryan O WaltersDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Esperanza AriasDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Antonio DiazDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Emmanuel S BurgosDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Fangxia GuanDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Simoni TianoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Kai MaoDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Cara L GreenInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
Yungping QiuDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Einstein-Mount Sinai Diabetes Research Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine, Bronx, New York, USA.
Hardik ShahDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Einstein-Mount Sinai Diabetes Research Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine, Bronx, New York, USA.
Donghai WangDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Adam D HudginsDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Tahmineh TabrizianDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Valeria TostiDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
David ShechterDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Luigi FontanaCharles Perkins Centre, The University of Sydney, NSW 2006, Australia; Central Clinical School, The University of Sydney, NSW 2006, Australia; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Clinical and Experimental Sciences, Brescia University Medical School, Brescia, Italy.
Irwin J KurlandDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Einstein-Mount Sinai Diabetes Research Center, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine, Bronx, New York, USA.
Nir BarzilaiDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA.
Daniel E L PromislowDepartment of Pathology, University of Washington, Seattle, WA, USA; Department of Biology, University of Washington, Seattle, WA, USA.
Derek M HuffmanDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: derek.huffman@einstein.yu.edu.
Albert Einstein College of Medicine · USUniversity of Aberdeen · GBUniversity of Sydney · AUUniversity of Washington · USWashington University in St. Louis · US
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2009 to 2024
$36.2MRESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0MSPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MUniversity of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1MSpecial Animal CoreP30DK041296 · NIDDK · YESHIVA UNIVERSITY · PI GUPTA, SANJEEV · 1989 to 2018
$22.9MTRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2010 to 2024
$10.8MTraining in Aging ResearchT32AG023475 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NIR J BARZILAI, DEREK Major HUFFMAN · 2004 to 2026
$8.6MDecreased Protein Degradation in AgingR37AG021904 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2013 to 2022
$4.4MDysregulation of Glucose Homeostasis in AgingR37AG018381 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2010 to 2019
$3.5MNCI NIH HHS P30 CA013330NIA NIH HHS P01 AG001751NIA NIH HHS P01 AG031782NIA NIH HHS P30 AG013280NIA NIH HHS P30 AG038072NIA NIH HHS R00 AG037574NIA NIH HHS R01 AG018381NIA NIH HHS R01 AG049494NIA NIH HHS R37 AG018381NIA NIH HHS R37 AG021904NIA NIH HHS R56 AG052981NIA NIH HHS T32 AG023475NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK026687NIDDK NIH HHS P30 DK041296NIGMS NIH HHS R01 GM108646NIGMS NIH HHS T32 GM007491
Abstract
A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of the rat metabolome than age in plasma and tissues. A comparative metabolomic screen in rodents and humans identified circulating sarcosine as being similarly reduced with aging and increased by DR, while sarcosine is also elevated in long-lived Ames dwarf mice. Pathway analysis in aged sarcosine-replete rats identify this biogenic amine as an integral node in the metabolome network. Finally, we show that sarcosine can activate autophagy in cultured cells and enhances autophagic flux in vivo, suggesting a potential role in autophagy induction by DR. Thus, these data identify circulating sarcosine as a biomarker of aging and DR in mammalians and may contribute to age-related alterations in the metabolome and in proteostasis.
Indexed as
Caloric RestrictionLongevityMetabolomeAdultAgedAgingAnimalsBiomarkersCohort StudiesFemaleHomeostasisHumansMaleMiceMiddle AgedRatsBiomarkersSarcosineagingamino acidsautophagydietary restrictionglycerophospholipidsglycineGNMTmetabolomicsmethioninesarcosine
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