Evidence map›Paper›PMID 30332561›Full record

ReviewAnnual review of pathology2019

Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers.

Perry V Halushka, Andrew J Goodwin, Marc K Halushka

Abstract readReview
In one paragraph

Review in Annual review of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
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  9. Review
  10. Research progress of non-coding RNA in atrial fibrillation.Frontiers in cardiovascular medicine · 2023
    Review
  11. Review
  12. MiR-199a-3p promotes repair of myocardial infarction by targeting NACC2.International journal of clinical and experimental pathology · 2023
    Article
  13. The Role of MicroRNAs in Myocarditis-What Can We Learn from Clinical Trials?International journal of molecular sciences · 2022
    Review
  14. Article
  15. MicroRNAs as therapeutic targets in cardiovascular disease.The Journal of clinical investigation · 2022
    Review
  16. Article
  17. Exosomal RNAs in diagnosis and therapies.Non-coding RNA research · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Perry V HalushkaDepartment of Pharmacology, South Carolina Clinical and Translational Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA; email: halushpv@musc.edu.
Andrew J GoodwinDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA; email: goodwian@musc.edu.
Marc K HalushkaDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; email: mhalush1@jhmi.edu.

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Fine Dissection of Atherosclerosis Microenvironment RNA ExpressionR01HL137811 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALUSHKA, MARC K · 2017 to 2020
$2.4M
The Beneficial Effects of Endothelial Progenitor Cells in the Vascular Dysfunction of SepsisR01GM113995 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FAN, HONGKUAN · 2015 to 2019
$1.9M
The Role of Circulating Micro RNAs in ARDS Pathogenesis and OutcomesK23HL135263 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GOODWIN, ANDREW J · 2017 to 2019
$537k
NCATS NIH HHS UL1 TR001450NHLBI NIH HHS K23 HL135263NHLBI NIH HHS R01 HL137811NIGMS NIH HHS R01 GM113995
6 · The paper itself

Abstract

Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis. We present the current understanding of microRNAs as possible biomarkers in these categories and where their best opportunities exist to enter clinical practice.

Indexed as

Aortic Valve StenosisCardiovascular DiseasesCardiovascular SystemGenetic MarkersHeart FailureHumansHypertensionMicroRNAsMyocardial InfarctionGenetic MarkersMicroRNAsaortic stenosisbiomarkerscardiovascular diseasehypertensionmicroRNAssepsis

Identifiers

PMID30332561
PMCPMC6442682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.