ArticleAging2018
Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression.
Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation aging and transcriptomic studies in horses.Nature communications · 2022Pooled it
- Article
- Reversal of biological age in multiple rat organs by young porcine plasma fraction.GeroScience · 2024Article
- DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging.GeroScience · 2024Article
- Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice.Cellular reprogramming · 2024Article
- Article
- Pan-primate studies of age and sex.GeroScience · 2023Article
- Deconvolution of immune cell composition and biological age of hepatocellular carcinoma using DNA methylation.Methods (San Diego, Calif.) · 2023Article
- DNA methylation variations and epigenetic aging in telomere biology disorders.Scientific reports · 2023Article
- Development of DNA methylation-based epigenetic age predictors in loblolly pine (Pinus taeda).Molecular ecology resources · 2023Article
- Longitudinal study of epigenetic aging and its relationship with brain aging and cognitive skills in young adulthood.Frontiers in aging neuroscience · 2023Article
- Metabolo-epigenetic interplay provides targeted nutritional interventions in chronic diseases and ageing.Frontiers in oncology · 2023Review
- Cell-type Deconvolution and Age Estimation Using DNA Methylation Reveals NK Cell Deficiency in the Hepatocellular Carcinoma Microenvironment.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2022Article
- TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection.Journal of cell science · 2022Article
- Isolation of five different primary cell types from a single sample of human skin.STAR protocols · 2022Article
- DNA methylation clocks for dogs and humans.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hibernation slows epigenetic ageing in yellow-bellied marmots.Nature ecology & evolution · 2022Article
- Epigenetic clock and methylation studies in vervet monkeys.GeroScience · 2022Article
- In Silico Predictions on the Productive Life Span and Theory of Its Developmental Origin in Dairy Cows.Animals : an open access journal from MDPI · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The paramount role of senescent cells in ageing has prompted suggestions that re-expression of telomerase may prevent ageing; a proposition that is predicated on the assumption that senescent cells are the sole cause of ageing. Recently, several DNA methylation-based age estimators (epigenetic clocks) have been developed and they revealed that increased epigenetic age is associated with a host of age-related conditions, and is predictive of lifespan. Employing these clocks to measure epigenetic age
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.