Evidence map›Paper›PMID 30332344›Full record

ArticlePathogens and global health2018

Immune Stimulation of RAP domain binding protein (rTgRA15) from Toxoplasma gondii.

Min Han Lew, Rahmah Noordin, Mohammed Monsur Alam Khan, Gee Jun Tye

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Pathogens and global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. A Review on the Prevalence ofInternational journal of environmental research and public health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Min Han Lewa Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Minden , Penang , Malaysia.
Rahmah Noordina Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Minden , Penang , Malaysia.
Mohammed Monsur Alam Khana Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Minden , Penang , Malaysia.
Gee Jun Tyea Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Minden , Penang , Malaysia.ORCID 0000-0002-6707-9505
Universiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmosis, a parasitic disease in human and animals, is caused by Toxoplasma gondii. Our previous study has led to the discovery of a novel RAP domain binding protein antigen (TgRA15), an apparent in-vivo induced antigen recognised by antibodies in acutely infected individuals. This study is aimed to evaluate the humoral response and cytokine release elicited by recombinant TgRA15 protein in C57BL/6 mice, demonstrating its potential as a candidate vaccine for Toxoplasma gondii infection. In this study, the recombinant TgRA15 protein was expressed in Escherichia coli, purified and refolded into soluble form. C57BL/6 mice were immunised intradermally with the antigen and CASAC (Combined Adjuvant for Synergistic Activation of Cellular immunity). Antigen-specific humoral and cell-mediated responses were evaluated using Western blot and ELISA. The total IgG, IgG

Indexed as

AnimalsAntibodies, ProtozoanAntigens, ProtozoanFemaleImmunity, CellularImmunoglobulin GInterferon-gammaMice, Inbred C57BLProtozoan ProteinsProtozoan VaccinesRNA Recognition Motif ProteinsToxoplasmaToxoplasmosis, AnimalVaccines, SyntheticAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin GInterferon-gammaProtozoan ProteinsProtozoan VaccinesRNA Recognition Motif ProteinsVaccines, Syntheticantibodyimmunityinterferon gammamiceTgRAToxoplasmosisvaccine

Identifiers

PMID30332344
PMCPMC6300731
OpenAlexW2897279067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.