Evidence map›Paper›PMID 30332313›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease.

Archana Raman, Stephen C Parnell, Yan Zhang, Gail A Reif, Yuqiao Dai, Aditi Khanna, Emily Daniel, Corey White, Jay L Vivian, Darren P Wallace

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. TargetingbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Cell-cell communication in kidney fibrosis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  11. Article
  12. Article
  13. Targeting integrin pathways: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2023
    Review
  14. Article
  15. Article
  16. Kidney stone formation in a novel murine model of polycystic kidney disease.American journal of physiology. Renal physiology · 2022
    Article
  17. Article
  18. The role of periostin in kidney diseases.Central-European journal of immunology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Archana RamanThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Stephen C ParnellThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Yan ZhangThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Gail A ReifThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Yuqiao DaiThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Aditi KhannaThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Emily DanielThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Corey WhiteThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
Jay L VivianDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center , Kansas City, Kansas.
Darren P WallaceThe Jared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.
University of Kansas Medical Center · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VIVIAN, JAY L · 2017 to 2021
$5.6M
Pilot and Feasibility CoreP30DK106912 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CALVET, JAMES P · 2015 to 2019
$5.5M
Role of Periostin in Polycystic Kidney DiseaseR01DK081579 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WALLACE, DARREN P. · 2009 to 2018
$3.0M
NCI NIH HHS P30 CA168524NICHD NIH HHS U54 HD090216NIDDK NIH HHS P30 DK079328NIDDK NIH HHS P30 DK106912NIDDK NIH HHS R01 DK081579NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM122731
6 · The paper itself

Abstract

In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix production contributes to cyst growth and fibrosis, leading to progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is overexpressed by cystic epithelial cells of PKD kidneys. Periostin binds α

Indexed as

Cell ProliferationAdultAgedAnimalsCase-Control StudiesCell Adhesion MoleculesCell MovementCells, CulturedDisease Models, AnimalDisease ProgressionEpithelial CellsExtracellular MatrixFemaleFibrosisGene Expression RegulationGenetic Predisposition to DiseaseCell Adhesion MoleculesPkhd1 protein, mousePOSTN protein, humanPostn protein, mouseReceptors, Cell Surfaceautosomal dominant polycystic kidney diseaseextracellular matrixintegrinmatricellular proteinproliferation

Identifiers

PMID30332313
PMCPMC6336984
OpenAlexW2895889363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.