ArticleBrain and behavior2018
Variability of the medullary arcuate nucleus in humans.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 13 citations in OpenAlex.
- Variability of anterior external arcuate fibers in the human medulla oblongata.Anatomy & cell biology · 2025Article
- Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development.Advances in experimental medicine and biology · 2023Review
- Comparative analysis of four nuclei in the human brainstem: Individual differences, left-right asymmetry, species differences.Frontiers in neuroanatomy · 2023Article
- Harmful Effect of Intrauterine Smoke Exposure on Neuronal Control of "Fetal Breathing System" in Stillbirths.International journal of environmental research and public health · 2022Article
- A morphometric analysis of the circumolivary fiber bundle of the human brainstem.Frontiers in neuroanatomy · 2022Article
- Individual variability in the size and organization of the human arcuate nucleus of the medulla.Brain structure & function · 2022Article
- Hypertrophy of the Anterior External Arcuate Fasciculus: A Rare Variant With Implications for the Development of the Arcuate Nucleus.Frontiers in neuroanatomy · 2020Article
- Variability of the medullary arcuate nucleus in humans.Brain and behavior · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe arcuate nucleus is a component of the ventral medullary surface involved in chemoreception and breathing control. The hypoplasia of this nucleus is a very frequent finding in victims of sudden unexplained fetal and infant death (from the last weeks of pregnancy to the first year of life). On the contrary, this developmental alteration is rarely present in age-matched controls who died of defined causes. These observations lead to hypothesize that a well-developed and functional arcuate nucleus is generally required to sustain life. The aim of this study was to investigate whether the arcuate nucleus maintains the same supposed function throughout life.
methodsWe carried out neuropathological examinations of brainstems obtained from 25 adult subjects, 18 males and 7 females, aged between 34 and 89 years, who died from various causes.
resultsFor almost half of the cases (44%) microscopic examinations of serial histological sections of medulla oblongata showed a normal cytoarchitecture of the arcuate nucleus, extending along the pyramids. For the remaining 56% of cases, various degrees of hypodevelopment of this nucleus were observed, validated through the application of quantitative morphometric investigations, from decreased area, neuron number and volume, to full aplasia.
conclusionsThese unexpected findings indicate that the involvement of the arcuate nucleus in chemoreception in adulthood is questionable, given the possibility of living until late age without this nucleus. This opens new perspectives for researchers on the role and function of the arcuate nucleus in humans from birth to old age.
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