Evidence map›Paper›PMID 30329215›Full record

ArticleCellular microbiology2019

Aggregatibacter actinomycetemcomitans leukotoxin causes activation of lymphocyte function-associated antigen 1.

Patrik Nygren, Nataliya Balashova, Angela C Brown, Irene Kieba, Anuradha Dhingra, Kathleen Boesze-Battaglia, Edward T Lally

Abstract read
In one paragraph

Article in Cellular microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Honey Compounds Exhibit Antibacterial Effects AgainstAntibiotics (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Review
  4. Microorganisms · 2022
    Review
  5. Pathogens (Basel, Switzerland) · 2022
    Article
  6. Toxins · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Pathogens (Basel, Switzerland) · 2020
    Article
  11. Review
  12. Toxins · 2019
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Patrik NygrenDepartments of Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania.
Nataliya BalashovaDepartments of Pathology, School of Dental Medicine, and the Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-2444-6379
Angela C BrownDepartments of Pathology, School of Dental Medicine, and the Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-1038-8216
Irene KiebaDepartments of Pathology, School of Dental Medicine, and the Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Anuradha DhingraDepartments of Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania.
Kathleen Boesze-BattagliaDepartments of Biochemistry, University of Pennsylvania, Philadelphia, Pennsylvania.
Edward T LallyDepartments of Pathology, School of Dental Medicine, and the Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · US

Funding

VIRULENCE FACTORS IN PERIODONTAL DISEASER01DE009517 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BALASHOVA, NATALIYA V · 1990 to 2018
$5.2M
MEMBRANE FUSION IN RETINAL ROD OUTER SEGMENTSR01EY010420 · NEI · UNIV OF MED/DENT NJ-SCH OSTEOPATHIC MED · PI BOESZE-BATTAGLIA, KATHLEEN · 1999 to 2016
$4.7M
Lysosomal maturation during periodontal infectionsR01DE022465 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BOESZE-BATTAGLIA, KATHLEEN · 2012 to 2016
$2.0M
Mechanism of LtxA Enrichment in A. Actinomycetemcomitans Outer Membrane VesiclesR21DE027769 · NIDCR · LEHIGH UNIVERSITY · PI BROWN, ANGELA C. · 2018 to 2019
$426k
Cytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxinK99DE022795 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BROWN, ANGELA C. · 2012 to 2013
$155k
Interaction of Aggregatibacter actinomycetemcomitans leukotoxin with membranesF32DE020950 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BROWN, ANGELA C. · 2010 to 2012
$123k
NEI NIH HHS R01 EY010420NIDCR NIH HHS F32 DE020950NIDCR NIH HHS K99 DE022795NIDCR NIH HHS R01 DE009517NIDCR NIH HHS R01 DE022465NIDCR NIH HHS R21 DE027769
6 · The paper itself

Abstract

Repeats-in-toxin leukotoxin (LtxA) produced by the oral bacterium Aggregatibacter actinomycetemcomitans kills human leukocytes in a lymphocyte function-associated antigen 1 (LFA-1, integrin α

Indexed as

Host-Pathogen InteractionsAggregatibacter actinomycetemcomitansExotoxinsFluorescence Resonance Energy TransferHumansImmunosuppressive AgentsJurkat CellsLymphocyte Function-Associated Antigen-1Microscopy, FluorescenceProtein BindingExotoxinsImmunosuppressive AgentsleukotoxinLymphocyte Function-Associated Antigen-1integrinleukotoxin (LtxA)LFA-1microbial pathogenesisRTX toxinsurface plasmon resonance (SPR)

Identifiers

PMID30329215
PMCPMC6657692
OpenAlexW2897942209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.